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[4-chloro-3-(3-chloro-5-cyanophenoxy)-2-fluorophenyl]acetic acid ethyl ester

[4-chloro-3-(3-chloro-5-cyanophenoxy)-2-fluorophenyl]acetic acid ethyl ester

CAS号：867366-78-7

英文名：[4-chloro-3-(3-chloro-5-cyanophenoxy)-2-fluorophenyl]acetic acid ethyl ester

分子式：C17H12Cl2FNO3

分子量：368.186

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3-chloro-5-[(6-chloro-3-{[5-(2,5-dichloro-4-pyridinyl)-1,3,4-oxadiazol-2-yl]methyl}-2-fluorophenyl)oxy]benzonitrile

3-chloro-5-[(6-chloro-3-{[5-(2,5-dichloro-4-pyridinyl)-1,3,4-oxadiazol-2-yl]methyl}-2-fluorophenyl)oxy]benzonitrile

3-chloro-5-[(6-chloro-3-{[5-(3,5-dimethyl-1-{[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}-1H-pyrazol-4-yl)-1,3,4-oxadiazol-2-yl]methyl}-2-fluorophenyl)oxy]benzonitrile

3-chloro-5-[(6-chloro-3-{[5-(3,5-dimethyl-1-{[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}-1H-pyrazol-4-yl)-1,3,4-oxadiazol-2-yl]methyl}-2-fluorophenyl)oxy]benzonitrile

3-chloro-5-{[6-chloro-2-fluoro-3-({5-[4-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)phenyl]-1,3,4-oxadiazol-2-yl}methyl)phenyl]oxy}benzonitrile

3-chloro-5-{[6-chloro-2-fluoro-3-({5-[4-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)phenyl]-1,3,4-oxadiazol-2-yl}methyl)phenyl]oxy}benzonitrile

3-chloro-5-[(6-chloro-2-fluoro-3-{[5-(2-methyl-3-pyridinyl)-1,3,4-oxadiazol-2-yl]methyl}phenyl)oxy]benzonitrile

3-chloro-5-[(6-chloro-2-fluoro-3-{[5-(2-methyl-3-pyridinyl)-1,3,4-oxadiazol-2-yl]methyl}phenyl)oxy]benzonitrile

3-chloro-5-{[6-chloro-2-fluoro-3-({5-[3-fluoro-2-methyl-4-(methyloxy)phenyl]-1,3,4-oxadiazol-2-yl}methyl)phenyl]oxy}benzonitrile

3-chloro-5-{[6-chloro-2-fluoro-3-({5-[3-fluoro-2-methyl-4-(methyloxy)phenyl]-1,3,4-oxadiazol-2-yl}methyl)phenyl]oxy}benzonitrile

3-chloro-5-(6-chloro-3-((5-(5-chloro-1-(2-chlorobenzyl)-3-methyl-1H-pyrazol-4-yl)-1,3,4-oxadiazol-2-yl)methyl)-2-fluorophenoxy)benzonitrile

3-chloro-5-(6-chloro-3-((5-(5-chloro-1-(2-chlorobenzyl)-3-methyl-1H-pyrazol-4-yl)-1,3,4-oxadiazol-2-yl)methyl)-2-fluorophenoxy)benzonitrile

3-[5-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1,3,4-oxadiazol-2-yl]-N-[2-(4-morpholinyl)ethyl]benzamide

3-[5-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1,3,4-oxadiazol-2-yl]-N-[2-(4-morpholinyl)ethyl]benzamide

4-chloro-5-[5-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1,3,4-oxadiazol-2-yl]-2-fluoro-N-methylbenzenesulfonamide

4-chloro-5-[5-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1,3,4-oxadiazol-2-yl]-2-fluoro-N-methylbenzenesulfonamide

3-chloro-5-[(6-chloro-2-fluoro-3-{[5-(3-fluoro-4-hydroxy-2-methylphenyl)-1,3,4-oxadiazol-2-yl]methyl}phenyl)oxy]benzonitrile

3-chloro-5-[(6-chloro-2-fluoro-3-{[5-(3-fluoro-4-hydroxy-2-methylphenyl)-1,3,4-oxadiazol-2-yl]methyl}phenyl)oxy]benzonitrile

3-[5-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1,3,4-oxadiazol-2-yl]-N-[(2,2-dimethyl-1,3-dioxolan-4-yl)methyl]benzamide

3-[5-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1,3,4-oxadiazol-2-yl]-N-[(2,2-dimethyl-1,3-dioxolan-4-yl)methyl]benzamide

3-[5-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1,3,4-oxadiazol-2-yl]-N-(3-hydroxypropyl)benzamide

3-[5-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1,3,4-oxadiazol-2-yl]-N-(3-hydroxypropyl)benzamide

3-chloro-5-[(6-chloro-2-fluoro-3-{[5-(2-methyl-4-{[3-(4-morpholinyl)propyl]oxy}phenyl)-1,3,4-oxadiazol-2-yl]methyl}phenyl)oxy]benzonitrile

3-chloro-5-[(6-chloro-2-fluoro-3-{[5-(2-methyl-4-{[3-(4-morpholinyl)propyl]oxy}phenyl)-1,3,4-oxadiazol-2-yl]methyl}phenyl)oxy]benzonitrile

N'-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetyl)-5-methyl-2-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)-4-pyridinecarbohydrazide

N'-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetyl)-5-methyl-2-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)-4-pyridinecarbohydrazide

3-chloro-5-[(6-chloro-2-fluoro-3-{[5-(4-hydroxy-2-methylphenyl)-1,3,4-oxadiazol-2-yl]methyl}phenyl)oxy]benzonitrile

3-chloro-5-[(6-chloro-2-fluoro-3-{[5-(4-hydroxy-2-methylphenyl)-1,3,4-oxadiazol-2-yl]methyl}phenyl)oxy]benzonitrile

3-chloro-5-(6-chloro-2-fluoro-3-((5-(5-hydroxy-2-methylphenyl)-1,3,4-oxadiazol-2-yl)methyl)phenoxy)benzonitrile

3-chloro-5-(6-chloro-2-fluoro-3-((5-(5-hydroxy-2-methylphenyl)-1,3,4-oxadiazol-2-yl)methyl)phenoxy)benzonitrile

3-(3-((5-(2-bromo-3-hydroxy-4,6-dimethylphenyl)-1,3,4-oxadiazol-2-yl)methyl)-6-chloro-2- fluorophenoxy)-5-chlorobenzonitrile

3-(3-((5-(2-bromo-3-hydroxy-4,6-dimethylphenyl)-1,3,4-oxadiazol-2-yl)methyl)-6-chloro-2- fluorophenoxy)-5-chlorobenzonitrile

3-chloro-5-(6-chloro-2-fluoro-3-((5-(4-methyl-2-(pyridin-4-yl)-1H-imidazol-5-yl)-1,3,4-oxadiazol-2-yl)methyl)phenoxy)benzonitrile

3-chloro-5-(6-chloro-2-fluoro-3-((5-(4-methyl-2-(pyridin-4-yl)-1H-imidazol-5-yl)-1,3,4-oxadiazol-2-yl)methyl)phenoxy)benzonitrile

3-chloro-5-[(6-chloro-2-fluoro-3-{[5-(2-methyl-5-nitrophenyl)-1,3,4-oxadiazol-2-yl]methyl}phenyl)oxy]benzonitrile

3-chloro-5-[(6-chloro-2-fluoro-3-{[5-(2-methyl-5-nitrophenyl)-1,3,4-oxadiazol-2-yl]methyl}phenyl)oxy]benzonitrile

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3-chloro-5-[(6-chloro-3-{[5-(2,5-dichloro-4-pyridinyl)-1,3,4-oxadiazol-2-yl]methyl}-2-fluorophenyl)oxy]benzonitrile 3-chloro-5-[(6-chloro-3-{[5-(3,5-dimethyl-1-{[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}-1H-pyrazol-4-yl)-1,3,4-oxadiazol-2-yl]methyl}-2-fluorophenyl)oxy]benzonitrile 3-chloro-5-{[6-chloro-2-fluoro-3-({5-[4-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)phenyl]-1,3,4-oxadiazol-2-yl}methyl)phenyl]oxy}benzonitrile 3-chloro-5-[(6-chloro-2-fluoro-3-{[5-(2-methyl-3-pyridinyl)-1,3,4-oxadiazol-2-yl]methyl}phenyl)oxy]benzonitrile 3-chloro-5-(6-chloro-3-((5-(5-chloro-1-(2-chlorobenzyl)-3-methyl-1H-pyrazol-4-yl)-1,3,4-oxadiazol-2-yl)methyl)-2-fluorophenoxy)benzonitrile 3-chloro-5-[(6-chloro-2-fluoro-3-{[5-(2-methyl-4-{[3-(4-morpholinyl)propyl]oxy}phenyl)-1,3,4-oxadiazol-2-yl]methyl}phenyl)oxy]benzonitrile N'-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetyl)-5-methyl-2-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)-4-pyridinecarbohydrazide 3-chloro-5-[(6-chloro-2-fluoro-3-{[5-(4-hydroxy-2-methylphenyl)-1,3,4-oxadiazol-2-yl]methyl}phenyl)oxy]benzonitrile 3-chloro-5-(6-chloro-2-fluoro-3-((5-(4-methyl-2-(pyridin-4-yl)-1H-imidazol-5-yl)-1,3,4-oxadiazol-2-yl)methyl)phenoxy)benzonitrile N'-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetyl)-2-{[(2S)-2,3-dihydroxy-3-methylbutyl]oxy}-5-methyl-4-pyridinecarbohydrazide 3-chloro-5-[(6-chloro-3-{[5-(6-{[(2S)-2,3-dihydroxy-3-methylbutyl]oxy}-2-methyl-3-pyridinyl)-1,3,4-oxadiazol-2-yl]methyl}-2-fluorophenyl)oxy]benzonitrile 3-chloro-5-(6-chloro-2-fluoro-3-((5-(3-methyl-1H-pyrrol-2-yl)-1,3,4-oxadiazol-2-yl)methyl)phenoxy)benzonitrile 3-chloro-5-[(6-chloro-3-{[5-(6-{[(2S)-2,3-dihydroxy-3-methylbutyl]oxy}-4-methyl-3-pyridinyl)-1,3,4-oxadiazol-2-yl]methyl}-2-fluorophenyl)oxy]benzonitrile 3-chloro-5-[(6-chloro-3-{[5-(3,5-dimethyl-1H-pyrrol-2-yl)-1,3,4-oxadiazol-2-yl]methyl}-2-fluorophenyl)oxy]benzonitrile 3-chloro-5-{[6-chloro-3-({5-[(1Z)-1-cyano-2-(ethyloxy)-1-propen-1-yl]-1,3,4-oxadiazol-2-yl}methyl)-2-fluorophenyl]oxy}benzonitrile 3-chloro-5-[(6-chloro-2-fluoro-3-{[5-(4-{[3-hydroxy-2-(hydroxymethyl)propyl]oxy}phenyl)-1,3,4-oxadiazol-2-yl]methyl}phenyl)oxy]benzonitrile 3-chloro-5-(6-chloro-3-((5-(4-chloro-2-ethyl-1H-imidazol-5-yl)-1,3,4-oxadiazol-2-yl)methyl)-2-fluorophenoxy)benzonitrile 3-chloro-5-(6-chloro-3-((5-(3,4-dichlorofuran-2-yl)-1,3,4-oxadiazol-2-yl)methyl)-2-fluorophenoxy)benzonitrile N'-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetyl)-4-methyl-2-(methylsulfonyl)-1H-imidazole-5-carbohydrazide 3-[5-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1,3,4-oxadiazol-2-yl]-N-cyclopropylbenzamide 3-chloro-5-[(6-chloro-3-{[5-(2-chloro-4-methyl-1,3-thiazol-5-yl)-1,3,4-oxadiazol-2-yl]methyl}-2-fluorophenyl)oxy]benzonitrile 3-chloro-5-[(6-chloro-2-fluoro-3-{[5-(1-methyl-1H-imidazol-2-yl)-1,3,4-oxadiazol-2-yl]methyl}phenyl)oxy]benzonitrile 3-chloro-5-[(6-chloro-3-{[5-(cyanomethyl)-1,3,4-oxadiazol-2-yl]methyl}-2-fluorophenyl)oxy]benzonitrile 3-chloro-5-[(6-chloro-2-fluoro-3-{[5-(5-methyl-2-{[2-(methylsulfonyl)ethyl]amino}-4-pyridinyl)-1,3,4-oxadiazol-2-yl]methyl}phenyl)oxy]benzonitrile 3-chloro-5-[(6-chloro-2-fluoro-3-{[5-(2-methyl-4-{[2-(4-morpholinyl)ethyl]oxy}phenyl)-1,3,4-oxadiazol-2-yl]methyl}phenyl)oxy]benzonitrile 3-chloro-5-{[6-chloro-3-({[5-chloro-2-(methylthio)-4-pyridinyl]-1,3,4-oxadiazol-2-yl}methyl)-2-fluorophenyl]oxy}benzonitrile 3-chloro-5-[(6-chloro-2-fluoro-3-{[5-(4-methyl-1H-imidazol-5-yl)-1,3,4-oxadiazol-2-yl]methyl}phenyl)oxy]benzonitrile 3-chloro-5-{[6-chloro-2-fluoro-3-({5-[4-methyl-2-(methylsulfonyl)-1H-imidazol- 5-yl]-1,3,4-oxadiazol-2-yl}methyl)phenyl]oxy}benzonitrile 3-chloro-5-[(6-chloro-2-fluoro-3-{[5-(4-methyl-1H-pyrazol-5-yl)-1,3,4-oxadiazol-2-yl]methyl}phenyl)oxy]benzonitrile 3-chloro-5-{[6-chloro-2-fluoro-3-({5-[2-methyl-4-(methyloxy)phenyl]-1,3,4-oxadiazol-2-yl}methyl)phenyl]oxy}benzonitrile 3-[(3-{[5-(3-amino-5-methyl-1H-pyrazol-4-yl)-1,3,4-oxadiazol-2-yl]methyl}-6-chloro-2-fluorophenyl)oxy]-5-chlorobenzonitrile 3-chloro-5-[(6-chloro-3-{[5-(1,4-dimethyl-1H-imidazol-5-yl)-1,3,4-oxadiazol-2-yl]methyl}-2-fluorophenyl)oxy]benzonitrile 3-chloro-5-{[6-chloro-2-fluoro-3-({5-[5-methyl-2-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)-4-pyridinyl]-1,3,4-oxadiazol-2-yl}methyl)phenyl]oxy}benzonitrile 3-chloro-5-({6-chloro-3-[(5-{3,5-dimethyl-1-[2-(methylsulfonyl)ethyl]-1H-pyrazol-4-yl}-1,3,4-oxadiazol-2-yl)methyl]-2-fluorophenyl}oxy)benzonitrile 3-chloro-5-[(6-chloro-3-{[5-(2-{[(2S)-2,3-dihydroxy-3-methylbutyl]oxy}-5-methyl-4-pyridinyl)-1,3,4-oxadiazol-2-yl]methyl}-2-fluorophenyl)oxy]benzonitrile 3-chloro-5-({6-chloro-3-[(5-{1-[(2S)-2,3-dihydroxy-3-methylbutyl]-3,5-dimethyl-1H-pyrazol-4-yl}-1,3,4-oxadiazol-2-yl)methyl]-2-fluorophenyl}oxy)benzonitrile 4-chloro-5-[5-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1,3,4-oxadiazol-2-yl]-2-fluorobenzenesulfonamide N'-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetyl)-4-methyl-1H-pyrazole-5-carbohydrazide 3-chloro-5-{[6-chloro-2-fluoro-3-({5-[4-methyl-6-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)-3-pyridinyl]-1,3,4-oxadiazol-2-yl}methyl)phenyl]oxy}benzonitrile 3-chloro-5-{[6-chloro-2-fluoro-3-({5-[2-methyl-6-({[(4S)-2,2,5,5-tetramethyl-1,3-dioxolan-4-yl]methyl}oxy)-3-pyridinyl]-1,3,4-oxadiazol-2-yl}methyl)phenyl]oxy}benzonitrile 3-chloro-5-[(6-chloro-3-{[5-(4-{[(2S)-2,3-dihydroxy-3-methylbutyl]oxy}phenyl)-1,3,4-oxadiazol-2-yl]methyl}-2-fluorophenyl)oxy]benzonitrile 3-chloro-5-[(6-chloro-3-{[5-(4-{[(2,2-dimethyl-1,3-dioxan-5-yl)methyl]oxy}phenyl)-1,3,4-oxadiazol-2-yl]methyl}-2-fluorophenyl)oxy]benzonitrile 3-chloro-5-{[6-chloro-3- ({5-[(1E)-1-cyano-2-(ethyloxy)-1-propen-1-yl]-1,3,4-oxadiazol-2-yl}methyl)-2- fluorophenyl]oxy}benzonitrile 1,1-dimethylethyl (3R)-3-[({4-[5-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}methyl)-1,3,4-oxadiazol-2-yl]-3-methylphenyl}oxy)methyl]-1-piperidinecarboxylate 3-chloro-5-[(6-chloro-2-fluoro-3-{[5-(4-methyl-2-oxo-2,3-dihydro-1,3-thiazol-5-yl)-1,3,4-oxadiazol-2-yl]methyl}phenyl)oxy]benzonitrile 3-chloro-5-[(6-chloro-3-{[5-(1,4-dimethyl-1H-pyrazol-5-yl)-1,3,4-oxadiazol-2-yl]methyl}-2-fluorophenyl)oxy]benzonitrile 3-chloro-5-[(6-chloro-2-fluoro-3-{[5-(4-methyl-2-{[2-(methylsulfonyl)ethyl]amino}-1,3-thiazol-5-yl)-1,3,4-oxadiazol-2-yl]methyl}phenyl)oxy]benzonitrile N'-({4-chloro-3-[(3-chloro-5-cyanophenyl)oxy]-2-fluorophenyl}acetyl)-4-methyl-1H-imidazole-5-carbohydrazide 3-chloro-5-[(6-chloro-2-fluoro-3-{[5-(2-fluoro-5-methyl-4-pyridinyl)-1,3,4-oxadiazol-2-yl]methyl}phenyl)oxy]benzonitrile