百科

(R)-1-{(S)-2-[2-((2S,9R)-2-Amino-9-hydroxy-8-oxo-decanoylamino)-2-methyl-propionylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid

(R)-1-{(S)-2-[2-((2S,9R)-2-Amino-9-hydroxy-8-oxo-decanoylamino)-2-methyl-propionylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid

CAS号：874384-22-2

英文名：(R)-1-{(S)-2-[2-((2S,9R)-2-Amino-9-hydroxy-8-oxo-decanoylamino)-2-methyl-propionylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid

分子式：C28H42N4O7

分子量：546.656

合成路线

(S)-2-dibenzylamino-5-hydroxypentanoic acid benzyl ester

(S)-2-dibenzylamino-5-hydroxypentanoic acid benzyl ester

(R)-1-{(S)-2-[2-((2S,9R)-2-Amino-9-hydroxy-8-oxo-decanoylamino)-2-methyl-propionylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid

(R)-1-{(S)-2-[2-((2S,9R)-2-Amino-9-hydroxy-8-oxo-decanoylamino)-2-methyl-propionylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid

benzyl (S)-2-(dibenzylamino)pent-4-enoate

benzyl (S)-2-(dibenzylamino)pent-4-enoate

(R)-1-{(S)-2-[2-((2S,9R)-2-Amino-9-hydroxy-8-oxo-decanoylamino)-2-methyl-propionylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid

(R)-1-{(S)-2-[2-((2S,9R)-2-Amino-9-hydroxy-8-oxo-decanoylamino)-2-methyl-propionylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid

(E)-(S)-2-Dibenzylamino-6-methoxy-hex-5-enoic acid benzyl ester

(E)-(S)-2-Dibenzylamino-6-methoxy-hex-5-enoic acid benzyl ester

(R)-1-{(S)-2-[2-((2S,9R)-2-Amino-9-hydroxy-8-oxo-decanoylamino)-2-methyl-propionylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid

(R)-1-{(S)-2-[2-((2S,9R)-2-Amino-9-hydroxy-8-oxo-decanoylamino)-2-methyl-propionylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid

(S)-2-(dibenzylamino)-6-oxohexanoic acid benzyl ester

(S)-2-(dibenzylamino)-6-oxohexanoic acid benzyl ester

(R)-1-{(S)-2-[2-((2S,9R)-2-Amino-9-hydroxy-8-oxo-decanoylamino)-2-methyl-propionylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid

(R)-1-{(S)-2-[2-((2S,9R)-2-Amino-9-hydroxy-8-oxo-decanoylamino)-2-methyl-propionylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid

Bzl-N(Bzl)Glu(OBzl)-OBzl

Bzl-N(Bzl)Glu(OBzl)-OBzl

(R)-1-{(S)-2-[2-((2S,9R)-2-Amino-9-hydroxy-8-oxo-decanoylamino)-2-methyl-propionylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid

(R)-1-{(S)-2-[2-((2S,9R)-2-Amino-9-hydroxy-8-oxo-decanoylamino)-2-methyl-propionylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid

2-dibenzylamino-5-oxo-pentanoic acid benzyl ester

2-dibenzylamino-5-oxo-pentanoic acid benzyl ester

(R)-1-{(S)-2-[2-((2S,9R)-2-Amino-9-hydroxy-8-oxo-decanoylamino)-2-methyl-propionylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid

(R)-1-{(S)-2-[2-((2S,9R)-2-Amino-9-hydroxy-8-oxo-decanoylamino)-2-methyl-propionylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid

(R)-1-((S)-2-{2-[(2S,9R)-2-tert-Butoxycarbonylamino-9-(tert-butyl-dimethyl-silanyloxy)-8-oxo-decanoylamino]-2-methyl-propionylamino}-3-phenyl-propionyl)-pyrrolidine-2-carboxylic acid

(R)-1-((S)-2-{2-[(2S,9R)-2-tert-Butoxycarbonylamino-9-(tert-butyl-dimethyl-silanyloxy)-8-oxo-decanoylamino]-2-methyl-propionylamino}-3-phenyl-propionyl)-pyrrolidine-2-carboxylic acid

(R)-1-{(S)-2-[2-((2S,9R)-2-Amino-9-hydroxy-8-oxo-decanoylamino)-2-methyl-propionylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid

(R)-1-{(S)-2-[2-((2S,9R)-2-Amino-9-hydroxy-8-oxo-decanoylamino)-2-methyl-propionylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid

(2S,9R)-2-(tert-butoxycarbonylamino)-9-(tert-butyldimethylsilyloxy)-8-oxo-6-decanoic acid

(2S,9R)-2-(tert-butoxycarbonylamino)-9-(tert-butyldimethylsilyloxy)-8-oxo-6-decanoic acid

(R)-1-{(S)-2-[2-((2S,9R)-2-Amino-9-hydroxy-8-oxo-decanoylamino)-2-methyl-propionylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid

(R)-1-{(S)-2-[2-((2S,9R)-2-Amino-9-hydroxy-8-oxo-decanoylamino)-2-methyl-propionylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid

Fmoc-D-脯氨酸

Fmoc-D-脯氨酸

(R)-1-{(S)-2-[2-((2S,9R)-2-Amino-9-hydroxy-8-oxo-decanoylamino)-2-methyl-propionylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid

(R)-1-{(S)-2-[2-((2S,9R)-2-Amino-9-hydroxy-8-oxo-decanoylamino)-2-methyl-propionylamino]-3-phenyl-propionyl}-pyrrolidine-2-carboxylic acid

上游原料

Fmoc-D-脯氨酸 Bzl-N(Bzl)Glu(OBzl)-OBzl benzyl (S)-2-(dibenzylamino)pent-4-enoate 2-dibenzylamino-5-oxo-pentanoic acid benzyl ester (S)-2-dibenzylamino-5-hydroxypentanoic acid benzyl ester (E)-(S)-2-Dibenzylamino-6-methoxy-hex-5-enoic acid benzyl ester (S)-2-(dibenzylamino)-6-oxohexanoic acid benzyl ester (2S,9R)-2-(tert-butoxycarbonylamino)-9-(tert-butyldimethylsilyloxy)-8-oxo-6-decanoic acid (R)-1-((S)-2-{2-[(2S,9R)-2-tert-Butoxycarbonylamino-9-(tert-butyl-dimethyl-silanyloxy)-8-oxo-decanoylamino]-2-methyl-propionylamino}-3-phenyl-propionyl)-pyrrolidine-2-carboxylic acid

下游产品

(-)-(3S,9S,14aR)-9-benzyl-3-[(R)-7-hydroxy-6-oxooctyl]-6,6-dimethyldecahydropyrrolo[1,2-a][1,4,7,10]tetraazacyclododecine-1,4,7,10-tetraone