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N-1-{(1R,2S,3S,4R)-2,3-bis(methoxymethoxy)-4-(hydroxymethyl)cyclopentyl}-5'-O-(tert-butyldimethylsilyl)-2',3'-O-isopropylideneadenosine

N-1-{(1R,2S,3S,4R)-2,3-bis(methoxymethoxy)-4-(hydroxymethyl)cyclopentyl}-5'-O-(tert-butyldimethylsilyl)-2',3'-O-isopropylideneadenosine

CAS号：933060-58-3

英文名：N-1-{(1R,2S,3S,4R)-2,3-bis(methoxymethoxy)-4-(hydroxymethyl)cyclopentyl}-5'-O-(tert-butyldimethylsilyl)-2',3'-O-isopropylideneadenosine

分子式：C29H49N5O9Si

分子量：639.813

合成路线

(1R,2S,3S,4R)-1-amino-2,3-bis(methoxymethoxy)-4-(hydroxymethyl)cyclopentane

(1R,2S,3S,4R)-1-amino-2,3-bis(methoxymethoxy)-4-(hydroxymethyl)cyclopentane

5-[(methoxymethylene)amino]-1-[5-O-(tert-butyldimethylsilyl)-2,3-O-(isopropylidene)-β-D-ribofuranosyl]imidazole-4-nitrile

5-[(methoxymethylene)amino]-1-[5-O-(tert-butyldimethylsilyl)-2,3-O-(isopropylidene)-β-D-ribofuranosyl]imidazole-4-nitrile

N-1-{(1R,2S,3S,4R)-2,3-bis(methoxymethoxy)-4-(hydroxymethyl)cyclopentyl}-5'-O-(tert-butyldimethylsilyl)-2',3'-O-isopropylideneadenosine

N-1-{(1R,2S,3S,4R)-2,3-bis(methoxymethoxy)-4-(hydroxymethyl)cyclopentyl}-5'-O-(tert-butyldimethylsilyl)-2',3'-O-isopropylideneadenosine

(1R,2S,3R,4R)-1-tert-butoxycarbonylamino-2-methoxymethoxy-3-hydroxy-4-(triisopropylsiloxymethyl)cyclopentane

(1R,2S,3R,4R)-1-tert-butoxycarbonylamino-2-methoxymethoxy-3-hydroxy-4-(triisopropylsiloxymethyl)cyclopentane

N-1-{(1R,2S,3S,4R)-2,3-bis(methoxymethoxy)-4-(hydroxymethyl)cyclopentyl}-5'-O-(tert-butyldimethylsilyl)-2',3'-O-isopropylideneadenosine

N-1-{(1R,2S,3S,4R)-2,3-bis(methoxymethoxy)-4-(hydroxymethyl)cyclopentyl}-5'-O-(tert-butyldimethylsilyl)-2',3'-O-isopropylideneadenosine

(1R,2S,3S,4R)-1-tert-butoxycarbonylamino-2-(methoxymethoxy)-3-hydroxy-4-(triisopropylsiloxymethyl)cyclopentane

(1R,2S,3S,4R)-1-tert-butoxycarbonylamino-2-(methoxymethoxy)-3-hydroxy-4-(triisopropylsiloxymethyl)cyclopentane

N-1-{(1R,2S,3S,4R)-2,3-bis(methoxymethoxy)-4-(hydroxymethyl)cyclopentyl}-5'-O-(tert-butyldimethylsilyl)-2',3'-O-isopropylideneadenosine

N-1-{(1R,2S,3S,4R)-2,3-bis(methoxymethoxy)-4-(hydroxymethyl)cyclopentyl}-5'-O-(tert-butyldimethylsilyl)-2',3'-O-isopropylideneadenosine

(1R,2S,3S,4R)-1-tert-butoxycarbonylamino-2,3-bis(methoxymethoxy)-4-(hydroxymethyl)cyclopentane

(1R,2S,3S,4R)-1-tert-butoxycarbonylamino-2,3-bis(methoxymethoxy)-4-(hydroxymethyl)cyclopentane

N-1-{(1R,2S,3S,4R)-2,3-bis(methoxymethoxy)-4-(hydroxymethyl)cyclopentyl}-5'-O-(tert-butyldimethylsilyl)-2',3'-O-isopropylideneadenosine

N-1-{(1R,2S,3S,4R)-2,3-bis(methoxymethoxy)-4-(hydroxymethyl)cyclopentyl}-5'-O-(tert-butyldimethylsilyl)-2',3'-O-isopropylideneadenosine

上游原料

5-[(methoxymethylene)amino]-1-[5-O-(tert-butyldimethylsilyl)-2,3-O-(isopropylidene)-β-D-ribofuranosyl]imidazole-4-nitrile (1R,2S,3S,4R)-1-tert-butoxycarbonylamino-2,3-bis(methoxymethoxy)-4-(hydroxymethyl)cyclopentane (1R,2S,3R,4R)-1-tert-butoxycarbonylamino-2-methoxymethoxy-3-hydroxy-4-(triisopropylsiloxymethyl)cyclopentane (1R,2S,3S,4R)-1-amino-2,3-bis(methoxymethoxy)-4-(hydroxymethyl)cyclopentane (1R,2S,3S,4R)-1-tert-butoxycarbonylamino-2-(methoxymethoxy)-3-hydroxy-4-(triisopropylsiloxymethyl)cyclopentane

下游产品

N-1-[(1R,2S,3S,4R)-2,3-bis(methoxymethoxy)-4-(hydroxymethyl)cyclopentyl]-5'-O-{bis(phenylsulfanyl)phosphoryl}-2',3'-O-isopropylideneadenosine N-1-{(1R,2S,3S,4R)-2,3-bis(methoxymethoxy)-4-[bis(4-methoxyphenyl)(phenyl)methoxymethyl]cyclopentyl}-5'-O-{bis(phenylsulfanyl)phosphoryl}-2',3'-O-isopropylideneadenosine