化合物简介
SC-5233 is a steroidal antimineralocorticoid of the spirolactone group that was developed by G. D. Searle & Company in the 1950s but was never marketed. It was the first antagonist of the mineralocorticoid receptor to have been identified and tested in humans. The drug was found to have poor oral bioavailability and potency, but it nonetheless produced a mild diuretic effect in patients with congestive heart failure. SC-8109, the 19-nor (19-demethyl) analogue, was developed and found to have improved oral bioavailability and potency, but still had relatively low potency. Spironolactone (SC-9420; Aldactone) followed and had both good oral bioavailability and potency, and was the first antimineralocorticoid to be marketed.
基本信息
中文名称
10,13-Dimethyl-1,6,7,8,9,10,11,12,13,14,15,16-dodecahydro-3'H-spi ro[cyclopenta[a]phenanthrene-17,2'-furan]-3,5'(2H,4'H)-dione
英文名称
10,13-Dimethyl-1,6,7,8,9,10,11,12,13,14,15,16-dodecahydro-3'H-spi ro[cyclopenta[a]phenanthrene-17,2'-furan]-3,5'(2H,4'H)-dione
中文别名
英文别名
(5r,8r,9r,10s,13s,14s,17s)-13-methyltetradecahydro-3\'h-spiro[cyclopenta[a]phenanthrene-17,2\'-furan]-3,5\'(2h,4\'h)-dione
CAS号
976-70-5
分子式
C22H30O3
分子量
342.472
精确质量
342.219
PSA
43.37
LOGP
4.5941
编号系统
EINECS号
213-552-4
物化性质
密度
1.17g/cm3
沸点
522.8ºC at 760 mmHg
闪点
228.9ºC
折射率
1.565