化合物简介
HET-0016 is a potent and selective inhibitor of the biosynthesis of 20-HETE acting via inhibition of CYP4A (IC50=8.9nM (human), 35nM (rat renal microsome). IC50 cyclooxygenase=2.3uM. IC50 for other CYP’s: CYP2C9-3.3uM, CYP2D6=83.9 uM, CYP3A4=71uM. It inhibits cerebrovascular constriction induced by Ca2+ or archidonate and inhibits angiogenesis and endothelial cell sprouting in various models. Displays protective effect on brain damage after temporary focal ischemia (at 10mg/Kg).
基本信息
中文名称
N-羟基-N’-(4-丁基-2-甲基苯基)甲脒
英文名称
N'-(4-butyl-2-methylphenyl)-N-hydroxymethanimidamide
中文别名
英文别名
HET0016、HMS1445D06
CAS号
339068-25-6
分子式
C12H18N2O
分子量
206.284
精确质量
206.142
PSA
44.62
LOGP
3.24
物化性质
密度
1.02g/cm3
沸点
356.9ºC at 760 mmHg
闪点
169.7ºC
折射率
1.524