化合物简介
Motesanib (AMG 706) is an experimental drug candidate originally developed by Amgen but is now being investigated by the Takeda Pharmaceutical Company. It is an orally administered small molecule belonging to angiokinase inhibitor class which acts as an antagonist of VEGF receptors, platelet-derived growth factor receptors, and stem cell factor receptors. It is used as the phosphate salt motesanib diphosphate.
基本信息
中文名称
莫特塞尼
英文名称
motesanib
中文别名
莫替沙尼、N-(2,3-二氢-3,3-二甲基-1H-吲哚-6-基)-2-[(4-吡啶甲基)氨基]-3-吡啶甲酰胺、3-吡啶甲酰胺,N-(2,3-二氢-3,3-二甲基-1H-吲哚-6-基)-2-[(4-吡啶基甲基)氨基]
英文别名
Motesanib Base
CAS号
453562-69-1
分子式
C22H23N5O
分子量
373.451
精确质量
373.19
PSA
78.94
LOGP
4.3281
编号系统
MDL号
MFCD10567689
物化性质
密度
1.251
沸点
517.258ºC at 760 mmHg
折射率
1.669
