MK-7246

MK-7246

CAS号：1218918-62-7

英文名：MK-7246

分子式

C21H21FN2O4S

熔点

密度

分子量

416.466

沸点

溶解度

信号词

危险品标志

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化合物简介

MK-7246 is a potent and selective CRTH2 antagonist for the treatment of respiratory diseases.

基本信息

中文名称

MK-7246

英文名称

MK-7246

中文别名

(R)-2-(7-(4-氟-N-甲基苯基磺酰胺)-6,7,8,9-四氢吡啶并[1,2-a]吲哚-10-基)乙酸

英文别名

2-[(7R)-7-(N-methyl4-fluorobenzenesulfonamido)、[3H]-2-[(7R)-7-[(4-fluorophenyl)sulfonyl-methylamino]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]acetic acid、Pyrido(1,2-a)indole-10-acetic acid,7-(((4-fluorophenyl)sulfonyl)methylamino)-6,7,8,9-tetrahydro-,(7R)、(+)-{7R-[[(4-fluorophenyl)sulfonyl](methyl)amino]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl}acetic acid、6H,7H,8H,9H-pyrido[1,2-a]indol-10-yl]acetic acid、[(7R)-7-[[(4-fluorophenyl)sulfonyl](methyl)amino]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]acetic acid

CAS号

1218918-62-7

分子式

C21H21FN2O4S

分子量

416.466

精确质量

416.121

PSA

87.99

LOGP

4.1238

合成路线

methyl [(7R)-7-[[(4-fluorophenyl)sulfonyl](methyl)amino]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]acetate

methyl [(7R)-7-[[(4-fluorophenyl)sulfonyl](methyl)amino]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]acetate

MK-7246

上游原料

共找到21个上游原料 >

ethyl 3-(6-oxo-1-phenyl-1,4,5,6-tetrahydropyridazin-3-yl)-propanoate

ethyl 3-(6-oxo-1-phenyl-1,4,5,6-tetrahydropyridazin-3-yl)-propanoate

ethyl 3-[3-(2-ethoxy-2-oxoethyl)-1H-indol-2-yl]propanoate

ethyl 3-[3-(2-ethoxy-2-oxoethyl)-1H-indol-2-yl]propanoate

(2R)-2-(2-[[tert-butyl(dimethyl)silyl]oxy]ethyl)-1-(4-fluorobenzenesulfonyl)aziridine

(2R)-2-(2-[[tert-butyl(dimethyl)silyl]oxy]ethyl)-1-(4-fluorobenzenesulfonyl)aziridine

ethyl (7-oxo-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)-acetate

ethyl (7-oxo-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)-acetate

tert-butyl 10-(2-ethoxy-2-oxoethyl)-7-oxo-6,7,8,9-tetrahydropyrido[1,2-a]indole-6-carboxylate

tert-butyl 10-(2-ethoxy-2-oxoethyl)-7-oxo-6,7,8,9-tetrahydropyrido[1,2-a]indole-6-carboxylate

dimethyl (2R)-2-[[(4-fluorophenyl)sulfonyl]amino]-butanedioate

dimethyl (2R)-2-[[(4-fluorophenyl)sulfonyl]amino]-butanedioate

上游原料

ethyl 3-(6-oxo-1-phenyl-1,4,5,6-tetrahydropyridazin-3-yl)-propanoate ethyl 3-[3-(2-ethoxy-2-oxoethyl)-1H-indol-2-yl]propanoate (2R)-2-(2-[[tert-butyl(dimethyl)silyl]oxy]ethyl)-1-(4-fluorobenzenesulfonyl)aziridine ethyl (7-oxo-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl)-acetate tert-butyl 10-(2-ethoxy-2-oxoethyl)-7-oxo-6,7,8,9-tetrahydropyrido[1,2-a]indole-6-carboxylate dimethyl (2R)-2-[[(4-fluorophenyl)sulfonyl]amino]-butanedioate ethyl (2-[4-[dimethyl(oxido)-λ4-sulfanylidene]-3-oxobutyl]-1H-indol-3-yl)acetate propyl {(7R)-7-{[(4-fluorophenyl)sulfonyl](methyl)amino}-6,7,8,9-tetrahydro-pyrido[1,2-a]indol-10-yl}acetate ethyl 3-[1-(2-tert-butoxy-2-oxoethyl)-3-(2-ethoxy-2-oxoethyl)-1H-indole-2-yl]propanoate ethyl [(7R)-7-amino-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]acetate hydrochloride (R)-methyl 2-(1-(4-((tert-butyldimethylsilyl)oxy)-2-(4-fluoro-N-methylphenylsulfonamido)butyl)-1H-indol-3-yl)acetate ethyl [(7R)-7-[[(4-fluorophenyl)sulfonyl](methyl)amino]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]acetate 2-[(2R)-1-[(4-fluorophenyl)sulfonyl]aziridin-2-yl]ethanol N-[(2R)-1,4-dihydroxybutan-2-yl]-4-fluorobenzenesulfonamide ethyl [(7R)-7-[[(4-fluorophenyl)sulfonyl]amino]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]acetate methyl (2R)-2-(1-[2-[4-fluoro-N-methylphenylsulfonamido]-4-hydroxybutyl]-1H-indol-3-yl)acetate 甲基吲哚-3-乙酸盐 methyl (R)-2-(1-(2-((4-fluoro-N-methylphenyl)sulfonamido)-4-oxobutyl)-1H-indol-3-yl)acetate 吲哚-3-乙酸 4-氧代庚二酸二乙酯 methyl [(7R)-7-[[(4-fluorophenyl)sulfonyl](methyl)amino]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]acetate