化合物简介
(S)-N-(3-chloro-4-fluorophenyl)-6-nitro-7-(tetrahydrofuran-3-yloxy)quinazolin-4-amine is a used in the synthetic preparation of 4-anilinoquinazolines with C-6 urea-linked side chains as inhibitors of epidermal growth factor receptor. It is also used in the preparation of (2Z)-Afatinib which is used for treating cancer and diseases of the respiratory tract, lungs, gastrointestinal tract, bile duct, and gallbladder.
基本信息
中文名称
N-(3-氯-4-氟苯基)-6-硝基-7-[[(3S)-四氢-3-呋喃基]氧基]-4-喹唑啉胺
英文名称
N-(3-chloro-4-fluorophenyl)-6-nitro-7-[(3S)-oxolan-3-yl]oxyquinazolin-4-amine
中文别名
4-[(3-氯-4-氟苯基)氨基]-6-硝基-7-((S)-四氢呋喃-3-基氧基)-喹唑啉
英文别名
(S)-N-(3-chloro-4-fluorophenyl)-6-nitro-7-(tetrahydrofuran-3-yloxy)quinazolin-4-amine、(S)-N-(3-chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine、4-[(3-Chloro-4-fluorophenyl)amino]-6-nitro-7-((5)-tetrahydrofuran-3-yloxy)-quinazoline、(2Z)-Afatinib intermediate
CAS号
314771-88-5
分子式
C18H14ClFN4O4
分子量
404.78
精确质量
404.069
PSA
102.09
LOGP
4.838
编号系统
MDL号
MFCD18642924
