化合物简介
Tetrahydropalmatine (THP) is an alkaloid found in several different plant species, mainly in the Corydalis genus (Yan Hu Suo), but also in other plants such as Stephania rotunda. These plants have traditional uses in Chinese herbal medicine. The pharmaceutical industry has synthetically produced the more potent enantiomer Levo-tetrahydropalmatine (Levo-THP), which has been marketed worldwide under different brand names as an alternative to anxiolytic and sedative drugs of the benzodiazepine group and analgesics such as opiates. It is also sold as a dietary supplement.
基本信息
中文名称
罗通定
英文名称
Tetrahydropalmatine
中文别名
左旋延胡索乙素、左旋四氢巴马汀、2,3,9,10-四甲氧基-5,8,13,13a-四氢-6H-二苯并[a,g]喹嗪
英文别名
D-Tetrahydropalmatin、levo-tetrahydropalmatine、Levo?tetrahydropalmatine
CAS号
10097-84-4
分子式
C21H25NO4
分子量
355.428
精确质量
355.178
PSA
40.16
LOGP
3.3144
物化性质
密度
1.23 g/cm3
沸点
482.9ºC at 760 mmHg
闪点
138.7ºC
折射率
1.608
蒸汽压
1.76E-09mmHg at 25°C
生产方法及用途
用途
用作镇痛药,适用于内科疾病引起的胃肠道和肝胆系统的头痛、痛经及分娩止痛