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(3R)-1-[2-氧代-2-[4-[4-(2-嘧啶基)苯基]-1-哌嗪基]乙基]-N-[3-(4-吡啶基)-1H-吲唑-5-基]-3-吡咯烷甲酰胺

(3R)-1-[2-氧代-2-[4-[4-(2-嘧啶基)苯基]-1-哌嗪基]乙基]-N-[3-(4-吡啶基)-1H-吲唑-5-基]-3-吡咯烷甲酰胺

CAS号:942183-80-4
英文名:(3R)-1-[2-oxo-2-[4-(4-pyrimidin-2-ylphenyl)piperazin-1-yl]ethyl]-N-(3-pyridin-4-yl-1H-indazol-5-yl)pyrrolidine-3-carboxamide
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化合物简介
SCH772984 is a novel and selective inhibitor of ERK1/2 that displays behaviors of both type I and type II kinase inhibitors and has nanomolar cellular potency in tumor cells with mutations in BRAF, NRA5, or KRAS and induces tumor regressions in xenograft models.
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