化合物简介
Nelotanserin (APD-125) is a drug developed by Arena Pharmaceuticals which acts as an inverse agonist on the serotonin receptor subtype 5-HT2A. It was shown to be effective and well tolerated in clinical trials, but development was halted in December 2008 because the substance did not meet the trial's endpoints. Research continues on newer analogues which may potentially be more successful.
基本信息
中文名称
1-[3-(4-溴-1-甲基-1H-吡唑-5-基)-4-甲氧基苯基]-3-(2,4-二氟苯基)脲
英文名称
1-[3-(4-bromo-2-methylpyrazol-3-yl)-4-methoxyphenyl]-3-(2,4-difluorophenyl)urea
中文别名
英文别名
Nelotanserin、APD125、UNII-4ZA73QEW2P
CAS号
839713-36-9
分子式
C18H15BrF2N4O2
分子量
437.238
精确质量
436.035
PSA
71.67
LOGP
4.867
编号系统
UNII
4ZA73QEW2P
物化性质
密度
1.55 g/cm3
沸点
425.886ºC at 760 mmHg
闪点
211.369ºC
合成路线