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丙酸氟替卡松

丙酸氟替卡松

CAS号：80474-14-2

英文名：fluticasone propionate

分子式

C25H31F3O5S

熔点

275 °C

密度

1.32 g/cm3

分子量

500.571

沸点

568.3ºC at 760 mmHg

溶解度

信号词

危险品标志

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化合物简介

Fluticasone propionate belongs to a class of drugs known as corticosteroids, specifically glucocorticoids, which are hormones that predominantly affect the metabolism of carbohydrates and, to a lesser extent, fat and protein. It is used to treat asthma, allergic rhinitis, nasal polyps, various skin disorders and Crohn's disease and ulcerative colitis. It is also used to treat eosinophilic esophagitis.

基本信息

中文名称

丙酸氟替卡松

英文名称

fluticasone propionate

中文别名

(6Α,11Β,16Α,17Α)-6,9-二氟-11-羟基-16-甲基-3-氧代17-(1-氧丙氧基)雄甾-1,4-二烯-17-硫代羧酸S-(氟甲基)酯、6,9-二氟-11羟基甲基氧代(氧代丙氧基)雄甾,二烯硫代羧酸-S-氟甲酯、氟替卡松丙酸酯

英文别名

FLIXONASE、FLIXOTIDE、FLUNASE、Flutide N、fluticasone propionate、Zoflut、FLOVENT、CUTIVATE、flutide、FLONASE、Fluticasone propionate

CAS号

80474-14-2

分子式

C25H31F3O5S

分子量

500.571

精确质量

500.184

PSA

105.97

LOGP

4.43

编号系统

MDL号

MFCD00866007

物化性质

外观与性状

结晶固体

密度

1.32 g/cm3

沸点

568.3ºC at 760 mmHg

熔点

275 °C

闪点

297.5ºC

折射率

31 ° (C=1, Dioxane)

储存条件

Store in original container in a cool dark place.

安全信息

RTECS号

BV7980000

安全说明

S22-S24/25

WGK Germany

2

海关编码

2937229000

生产方法及用途

生产方法

化合物(Ⅰ)先和N,N-二甲基硫代氯甲酰胺反应后,再水解得到相应的硫代羧酸(Ⅱ),然后和-溴-氟甲烷反应酯化,得丙酸氟替卡松。

用途

为局部有效的皮质甾体药物。用于抗过敏反应。

合成路线

S-hydroxymethyl 6α,9α-difluoro-16α-methyl-3-oxo-11β-hydroxy-17α-propionyloxyandrosta-1,4-diene-17β-carbothioate

S-hydroxymethyl 6α,9α-difluoro-16α-methyl-3-oxo-11β-hydroxy-17α-propionyloxyandrosta-1,4-diene-17β-carbothioate

丙酸氟替卡松

丙酸氟替卡松

海关数据

共找到1个国家海关数据 >

国家/地区名称	海关编码	更新时间	操作
中国	2937229000	2019-03	查看

上游原料

共找到20个上游原料 >

(6a,11b,16a,17a)-6,9-二氟-11,17-二羟基-16-甲基-3-氧代雄甾-1,4-二烯-17-硫代羧酸

(6a,11b,16a,17a)-6,9-二氟-11,17-二羟基-16-甲基-3-氧代雄甾-1,4-二烯-17-硫代羧酸

6,9-二氟-11,17-二羟基-16-甲基-3-氧代雄甾-1,4-二烯-17-羧酸

6,9-二氟-11,17-二羟基-16-甲基-3-氧代雄甾-1,4-二烯-17-羧酸

2-(((6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-10,13,16-trimethyl-3-oxo-17-(propionyloxy)-11-(2,2,2-trifluoroacetoxy)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carbonyl)thio)acetic acid

2-(((6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-10,13,16-trimethyl-3-oxo-17-(propionyloxy)-11-(2,2,2-trifluoroacetoxy)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carbonyl)thio)acetic acid

P-(monofluoromethyl)triphenylphosphonium tetrafluoroborate

P-(monofluoromethyl)triphenylphosphonium tetrafluoroborate

氯氟甲烷

(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-17-(((fluoromethyl)thio)carbonyl)-10,13,16-trimethyl-3-oxo-11-(2,2,2-trifluoroacetoxy)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate

(6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-17-(((fluoromethyl)thio)carbonyl)-10,13,16-trimethyl-3-oxo-11-(2,2,2-trifluoroacetoxy)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate

上游原料

(6a,11b,16a,17a)-6,9-二氟-11,17-二羟基-16-甲基-3-氧代雄甾-1,4-二烯-17-硫代羧酸 6,9-二氟-11,17-二羟基-16-甲基-3-氧代雄甾-1,4-二烯-17-羧酸 2-(((6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-10,13,16-trimethyl-3-oxo-17-(propionyloxy)-11-(2,2,2-trifluoroacetoxy)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carbonyl)thio)acetic acid P-(monofluoromethyl)triphenylphosphonium tetrafluoroborate 氯氟甲烷 (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-17-(((fluoromethyl)thio)carbonyl)-10,13,16-trimethyl-3-oxo-11-(2,2,2-trifluoroacetoxy)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate 氟替卡松丙酸酯中间体 N,N-二异丙基乙胺氟碘甲烷 (6a,11b,16a,17a)-6,9-二氟-11-羟基-16-甲基-3-氧代-17-(丙酰氧基)雄甾-1,4-二烯-17-羧酸溴氟甲烷 S-hydroxymethyl 6α,9α-difluoro-16α-methyl-3-oxo-11β-hydroxy-17α-propionyloxyandrosta-1,4-diene-17β-carbothioate S-fluoromethyl 6α-fluoro-9β,11β-epoxy-16α-methyl-17α-propionyloxy-3-oxoandrosta-1,4-diene-17β-carbothioate (6S,8S,9R,10S,11S,13S,14S,16R,17R)-6,9-difluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(propionyloxy)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthrene-17-carboxylic propionic thioanhydride 5-碘甲基6alpha,9alpha-二氟-11beta-羟基-16alpha-甲基-3-氧代-17alpha-(丙酰氧基)-雄甾-1,4-二烯-17beta-硫代甲酸酯 N-(monofluoromethyl)-N-phenyl-dimethylammonium triflate 氯硫卡松丙酸酯 3-(3,4-二甲氧基苯基)戊-2-酮