化合物简介
Cyclic guanosine monophosphate–adenosine monophosphate (cyclic GMP-AMP, cGAMP) is the first cyclic di-nucleotide found in metazoa. In mammalian cells, cGAMP is synthesized by cyclic GMP-AMP synthase (cGAS) from ATP and GTP upon cytosolic DNA stimulation. cGAMP produced by cGAS contains mixed phosphodiester linkages, with one between 2'-OH of GMP and 5'-phosphate of AMP and the other between 3'-OH of AMP and 5'-phosphate of GMP.
基本信息
中文名称
c-GpAp
英文名称
3'-Guanylic acid, adenylyl-(3'→5')-, cyclic nucleotide
中文别名
英文别名
Cyclic GMP-AMP、Cyclic AMP-GMP、cGAMP
CAS号
849214-04-6
分子式
C20H24N10O13P2
分子量
674.411
精确质量
674.1
PSA
349.27
LOGP
-1.1791
