美伐他汀

美伐他汀

CAS号：73573-88-3

英文名：mevastatin

分子式

C23H34O5

熔点

151-153°C

密度

1.13 g/cm3

分子量

390.513

沸点

555ºC at 760 mmHg

溶解度

信号词

危险品标志

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化合物简介

Mevastatin (compactin, ML-236B) is a hypolipidemic agent that belongs to the statins class.

基本信息

中文名称

美伐他汀

英文名称

mevastatin

中文别名

康百汀、2-甲基丁酸[1S-[1-Α(R*),7-Β,8-Β(2S*,4S*),8A-Β]]-1,2,3,7,8,8A-六氢-7-甲基-8-[2-(四氢-4-羟基-6-氧-2H-吡喃-2-基)乙基]-1-萘酯、康帕丁、辛可芬

英文别名

Compactin (penicillium)、[(1S,7S,8S,8aR)-8-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] (2S)-2-methylbutanoate、Antibiotic ML 236B、(+)-compactin、ML 236B、Mevastatin、Mevastatin (Compactin)、Mevastatinum [INN-Latin]

CAS号

73573-88-3

分子式

C23H34O5

分子量

390.513

精确质量

390.241

PSA

72.83

LOGP

3.9495

编号系统

UNII

1UQM1K0W9X

物化性质

外观与性状

白色粉末

密度

1.13 g/cm3

沸点

555ºC at 760 mmHg

熔点

151-153°C

闪点

186.5ºC

折射率

1.528

储存条件

2-8ºC

安全信息

RTECS号

EK7907100

安全说明

S22-S24/25

WGK Germany

3

危险类别码

R26/27/28

危险品标志

T+

合成路线

共找到3条合成路线 >

116996-42-0

美伐他汀

上游原料

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(3R,1'R)-methyl 1'-phenylethyl 3-((tert-butyldimethylsilyl)oxy)pentanedioate

(3R,1'R)-methyl 1'-phenylethyl 3-((tert-butyldimethylsilyl)oxy)pentanedioate

(4aα,8aβ)-5β,8α-bis(benzyloxy)-2(hydroxymethyl)-3-oxo-1β-[3-(1-ethoxyethoxy)propyl]decahydronaphthalene

(4aα,8aβ)-5β,8α-bis(benzyloxy)-2(hydroxymethyl)-3-oxo-1β-[3-(1-ethoxyethoxy)propyl]decahydronaphthalene

Ethyl 2-exo,3-endo-3-Nitro-7-oxabicyclo<2.2.1>heptane-2-carboxylate

Ethyl 2-exo,3-endo-3-Nitro-7-oxabicyclo<2.2.1>heptane-2-carboxylate

1β,4α-bis(benzyloxy)-7-oxo-1,2,3,4,4aβ,7,8,8aα-octahydronaphthalene

1β,4α-bis(benzyloxy)-7-oxo-1,2,3,4,4aβ,7,8,8aα-octahydronaphthalene

(1S,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-7-methyl-8-[2-((2R,4R)-tetrahydro-4-methoxy-6-oxo-2H-pyran-2-yl)-ethyl]-1-naphthyl (2S)-2-methylbutyrate

(1S,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-7-methyl-8-[2-((2R,4R)-tetrahydro-4-methoxy-6-oxo-2H-pyran-2-yl)-ethyl]-1-naphthyl (2S)-2-methylbutyrate

Hexanoic acid, 6-(dimethoxyphosphinyl)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-oxo-, (3R)-

Hexanoic acid, 6-(dimethoxyphosphinyl)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-oxo-, (3R)-

下游产品

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叔丁醇

普伐他汀

普伐他汀

上游原料

(3R,1'R)-methyl 1'-phenylethyl 3-((tert-butyldimethylsilyl)oxy)pentanedioate (4aα,8aβ)-5β,8α-bis(benzyloxy)-2(hydroxymethyl)-3-oxo-1β-[3-(1-ethoxyethoxy)propyl]decahydronaphthalene Ethyl 2-exo,3-endo-3-Nitro-7-oxabicyclo<2.2.1>heptane-2-carboxylate 1β,4α-bis(benzyloxy)-7-oxo-1,2,3,4,4aβ,7,8,8aα-octahydronaphthalene (1S,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-7-methyl-8-[2-((2R,4R)-tetrahydro-4-methoxy-6-oxo-2H-pyran-2-yl)-ethyl]-1-naphthyl (2S)-2-methylbutyrate Hexanoic acid, 6-(dimethoxyphosphinyl)-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-5-oxo-, (3R)- (1S-(1α,7β,8β(4S*,6R*),8aβ))-8-(2-(6-(2-(((1,1-Dimethylethyl)diphenylsilyl)oxy)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)ethyl)-1,2,6,7,8,8a-hexahydro-7-methyl-1-naphthalenol (4aα,8aβ)-5β,8α-bis(benzyloxy)-2-methylene-3-oxo-1β-[3-(1-ethoxyethoxy)propyl]decahydronaphthalene (R)-dimethyl <<4-<<(R)-phenylethoxy>carbonyl>-3-hydroxybutyryl>methyl>phosphonate 5β,8α-dihydroxy-2β-methyl-1β-[3-(1-ethoxyethoxy)propyl]-1,2,4aα,5,6,7,8,8aβ-octahydronaphthalene (S)-4-((1S,5S,6S)-6-(2-((4R,6S)-6-(2-((tert-butyldiphenylsilyl)oxy)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)ethyl)-5-methyl-2-oxocyclohex-3-en-1-yl)-4-((triethylsilyl)oxy)butanal (S)-(+)-2-甲基丁酸 (S)-(1S,7S,8S,8aR)-8-(2-((2R,4R)-4-((tert-butyldiphenylsilyl)oxy)-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2-methylbutanoate (1S,7S,8S,8aR)-8-(2-((4R,6S)-6-(2-((tert-butyldiphenylsilyl)oxy)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)ethyl)-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (S)-2-methylbutanoate (4S,5S,6S)-5-(2-((4R,6S)-6-(2-((tert-butyldiphenylsilyl)oxy)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)ethyl)-6-((R)-1-hydroxypent-4-en-1-yl)-4-methylcyclohex-2-en-1-one (2S,4aS,5R,8R,8aS)-5,8-bis(benzyloxy)-3-(phenylselanyl)decahydronaphthalen-2-ol methyl 3,5-dihydroxy-7-[2-methyl-8-(2-methylbutanoyloxy)-1,2,6,7,8,8a-hexahydronaphthalen-1-yl]heptanoate methyl (1R,4S)-7-oxabicyclo[2.2.1]hept-2-ene-2-carboxylate (1S,7S,8S,8aR)-8-(2-((4R,6R)-2,2-dimethyl-6-(2-oxoethyl)-1,3-dioxan-4-yl)ethyl)-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (S)-2-methylbutanoate 1β,4α-bis(benzyloxy)-7α-hydroxy-6β-(phenylselenyl)-4aβ,8aα-decahydronaphthalene 5β,8α-dibenzyloxy-2β-methyl-1β-[3-(1-ethoxyethoxy)propyl]-1,2,4aα,5,6,7,8,8aβ-octahydronaphthalene (4aα,8aβ)-5β,8α-bis(benzyloxy)-2α-methyl-3-oxo-1β-[3-(1-ethoxyethoxy)propyl]decahydronaphthalene 3-(叔丁基二甲基硅氧基)戊二酸酐 (4aS,5R,8R,8aS)-5,8-bis(benzyloxy)-1,2,4a,5,6,7,8,8a-octahydronaphthalen-2-ol (4aS,5R,8R,8aS)-5,8-bis(benzyloxy)-1,2,4a,5,6,7,8,8a-octahydronaphthalen-2-ol (1S,7S,8S,8aR)-8-formyl-7-methyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (S)-2-methylbutanoate (R)-dimethyl ((3-((tert-butyldimethylsilyl)oxy)-4-(((R)-phenylethoxy)carbonyl)butyryl)methyl)phosphonate ((1R,4aR,5S,8S,8aR)-5,8-bis(benzyloxy)-1-(3-(1-ethoxyethoxy)propyl)-3-oxodecahydronaphthalen-2-yl)methyl methanesulfonate (1S,2S,8S,8aR,5'R,2''S)-methyl 1,2,6,7,8,8a-hexahydro-3'-[(tert-butyldimethylsilyl)oxy]-2-methyl-8-[(2-methyl-1-oxobutyl)oxy]-3'-oxo-1-naphthalenehept-1'-enoate (4S,5S,6S)-5-(2-((4R,6S)-6-(2-((tert-butyldiphenylsilyl)oxy)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)ethyl)-4-methyl-6-((S)-1-((triethylsilyl)oxy)pent-4-en-1-yl)cyclohex-2-en-1-one methyl 3,5-dihydroxy-7-[(1'S,2'S,8'S,8a'S)-2'methyl-8'-[(S)-2-methylbutanoyloxy]-1',2',3',7',8',8a'-hexahydro-1'-naphthyl]heptanoate <4R-<4α(4R*,5R*),6α>>-5-<2-<6-<2-<<(1,1-dimethylethyl)diphenylsilyl>oxy>ethyl>-2,2-dimethyl-1,3-dioxan-4-yl>ethyl>-4-methyl-2-cyclohexen-1-one (3R,1'R)-methyl 1'-phenylethyl 3-hydroxypentanedioate (7S,8S,8aR)-8-(2-((4R,6S)-6-(2-((tert-butyldiphenylsilyl)oxy)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)ethyl)-7-methyl-3,7,8,8a-tetrahydronaphthalen-1(2H)-one (1S,2S,8S,8aR,5'R,2''S)-methyl 1,2,6,7,8,8a-hexahydro-5'hydroxy-2-methyl-8-((2-methyl-1-oxobutyl)oxy)-3'-oxo-1-naphthaleneheptanoate 1β,4α-bis(benzyloxy)-1,2,3,4,4aβ,5,8,8aα-octahydronaphthalene (+/-)-1,4,5,8,9,10-trans-hexahydronaphthalene-1,4-dione 7α-acetoxy-1β,4α-bis(benzyloxy)-6β-(phenylselenyl)-4aβ,8aα-decahydronaphthalene (2S,4aS,5R,8R,8aS)-5,8-bis(benzyloxy)-3-(phenylseleninyl)decahydronaphthalen-2-ol ethyl (1SR,2RS,3RS,4RS)-3-nitro-7-oxabicyclo[2.2.1]hept-5-ene-2-carboxylate (-)-(1S,4S,9R)-Δ6-trans-Octalin-1,4-diol

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丙酮叔丁醇普伐他汀普伐他汀