化合物简介
Endomorphin-1 (EM-1) (amino acid sequence Tyr-Pro-Trp-Phe-NH2) is an endogenous opioid peptide and one of the two endomorphins. It is a high affinity, highly selective agonist of the μ-opioid receptor, and along with endomorphin-2 (EM-2), has been proposed to be the actual endogenous ligand of the μ-receptor. EM-1 produces analgesia in animals and is equipotent with morphine in this regard. The gene encoding for EM-1 has not yet been identified.
基本信息
中文名称
内吗啡-1
英文名称
(2S)-1-[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]-N-[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]pyrrolidine-2-carboxamide
中文别名
TYR-PRO-TRP-PHE-NH2
英文别名
H-Tyr-Pro-Trp-Phe-NH2、Tyr-Pro-Trp-Phe、Endomorphin 1
CAS号
189388-22-5
分子式
C34H38N6O5
分子量
610.703
精确质量
610.29
PSA
183.64
LOGP
3.7949
物化性质
外观与性状
固体粉末
密度
1.343 g/cm3
沸点
1052.8ºC at 760 mmHg
闪点
590.5ºC
折射率
1.671
储存条件
-20ºC
蒸汽压
0mmHg at 25°C
