化合物简介
Cethromycin, trade name Restanza (initially known as ABT-773) is a ketolide antibiotic undergoing research for the treatment of community acquired pneumonia (CAP) and for the prevention of post-exposure inhalational anthrax, and was given an \"orphan drug\" status for this indication. Originally discovered and developed by Abbott, it was acquired by Advanced Life Sciences Inc. for further development.
基本信息
中文名称
喹红霉素
英文名称
(1R,2R,4R,6R,7R,8R,10R,13R,14S)-7-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-13-ethyl-2,4,6,8,10,14-hexamethyl-6-[(E)-3-quinolin-3-ylprop-2-enoxy]-12,15-dioxa-17-azabicyclo[12.3.0]heptadecane-3,9,11,16-tetrone
中文别名
英文别名
ABT 773、Restanza、Cethromycin
CAS号
205110-48-1
分子式
C42H59N3O10
分子量
765.932
精确质量
765.42
PSA
162.82
LOGP
5.4385
物化性质
密度
1.22g/cm3
沸点
927.1ºC at 760mmHg
闪点
514.5ºC
折射率
1.578
蒸汽压
0mmHg at 25°C
