化合物简介
Dacomitinib is an Erb-inhibitor, or an inhibitor of the members of the epidermal growth factor receptor family. Used as an ant-cancer agent due to observation of over-expressed epidermal growth factor receptor in nearly all cases of squamous cell carcinoma in the head and neck.
基本信息
中文名称
达克替尼
英文名称
Dacomitinib
中文别名
EGFR抑制剂
英文别名
Dacomitinib [USAN]、(2e)-N-{4-[(3-Chloro-4-Fluorophenyl)amino]-7-Methoxyquinazolin-6-Yl}-4-(Piperidin-1-Yl)but-2-Enamide、(2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-4-(1-piperidinyl)-2-butenamide、Dacomitinib (USAN/INN)、(E)-N-[4-(3-chloro-4-fluoroanilino)-7-methoxyquinazolin-6-yl]-4-piperidin-1-ylbut-2-enamide
CAS号
1110813-31-4
分子式
C24H25ClFN5O2
分子量
469.939
精确质量
469.168
PSA
79.38
LOGP
5.239
编号系统
MDL号
MFCD19443734
