化合物简介
Phosphorylated Combretastatin, a small organic molecule found in the bark of the African bush willow tree Combretum caffrum. Combretastatin-A4 Prodrug Induces Mitotic Catastrophe in Chronic Lymphocytic Leukemia Cell Line Independent of Caspase Activation and Poly(ADP-ribose) Polymerase Cleavage. A potent cytotoxic agent which strongly inhibits the polymerization of tubulin by binding to the colchicine site.
基本信息
中文名称
考布他丁 A-4 磷酸二钠盐
英文名称
disodium,[2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl] phosphate
中文别名
康布瑞汀磷酸二钠、康普瑞汀磷酸二钠
英文别名
Zybrestat、Fosbretabulin disodium、CA4DP、Fosbretabulin disodium (USAN)、Combretastatin A-4 phosphate、Fosbretabulin (Combretastatin A4 Phosphate (CA4P)) Disodium、Combretastatin A4 disodium phosphate
CAS号
168555-66-6
分子式
C18H19Na2O8P
分子量
440.292
精确质量
440.061
PSA
119.15
LOGP
4.2393
编号系统
UNII
702RHR475O
物化性质
外观与性状
白色固体
沸点
611.8ºC at 760 mmHg
熔点
238-242ºC
蒸汽压
7.99E-16mmHg at 25°C
