化合物简介
Meclizine (INN, or meclozine) is an antihistamine considered to be an antiemetic. It is sold under the brand names Bonine, Bonamine, Antivert, Postafen, Sea Legs, and Dramamine II (Less Drowsy Formulation). Emesafene is a combination of meclizine (1/3) and pyridoxine (2/3). In Canada, Antivert Tab (which is no longer available) was a combination of meclizine and nicotinic acid.
基本信息
中文名称
美克洛嗪
英文名称
1-[(4-chlorophenyl)-phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine
中文别名
1-[(4-氯苯基)苯甲基]-4-[(3-甲苯基)甲基]-哌嗪、氯苯苄嗪
英文别名
Piperazine, 1-[(4-chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]-、meclizine、Meclozine、Histamethizine、Navicalm、Bonadettes、Chiclida、1-[(4-Chlorophenyl)phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine、Bonine、Sea-Legs、Parachloramine、1-(4-chloro-benzhydryl)-4-(3-methyl-benzyl)-piperazine、Histamethine
CAS号
569-65-3
分子式
C25H28Cl2N2
分子量
427.409
精确质量
426.163
PSA
6.48
LOGP
6.2334
编号系统
MDL号
MFCD00242697
物化性质
密度
1.159 g/cm3
沸点
1.5 g/100 mL (25ºC)
熔点
153-157ºC
闪点
253.3ºC
储存条件
Keep in a cool, dry, dark location in a tightly sealed container or cylinder. Keep away from incompatible materials, ignition sources and untrained individuals. Secure and label area. Protect containers/cylinders from physical damage.
安全信息
安全说明
S26-S37/39
危险类别码
R22; R36/37/38
海关编码
2933599090
危险品标志
Xn
生产方法及用途
用途
抗组胺药。有镇吐和抗眩晕作用。用于防治晕动病。
