化合物简介
CI-966 (developmental code name) is a central nervous system depressant acting as a GABA reuptake inhibitor, specifically a highly potent and selective blocker of the GABA transporter 1 (GAT-1) (IC50 = 0.26 µM), and hence indirect and non-selective GABA receptor full agonist. It was investigated as a potential anticonvulsant, anxiolytic, and neuroprotective therapeutic but was discontinued during clinical development due to the incidence of severe adverse effects at higher doses and hence was never marketed.
基本信息
中文名称
1-[2-[二[4-(三氟甲基)苯基]甲氧基]乙基]-5,6-二氢-2H-吡啶-3-羧酸
英文名称
1-[2-[bis[4-(trifluoromethyl)phenyl]methoxy]ethyl]-3,6-dihydro-2H-pyridine-5-carboxylic acid
中文别名
英文别名
1-(2-(Bis(4-(trifluoromethyl)phenyl)methoxy)ethyl)-1,2,5,6-tetrahydropyridine-3-carboxylic acid、1-[2-[bis[4-(trifluoromethyl)phenyl]methoxy]ethyl]-1,2,5,6-tetrahydro-3-pyridine carboxylic acid、CI-966、1,2,5,6-tetrahydro-1-<2-<bis<4-(trifluoromethyl)phenyl>methoxy>ethyl>-3-pyridinecarboxylic acid、3-Pyridinecarboxylicacid,1-[2-[bis[4-(trifluoromethyl)phenyl]methoxy]ethyl]-1,2,5,6-tetrahydro、Tocris-1296
CAS号
110283-79-9
分子式
C23H21F6NO3
分子量
473.408
精确质量
473.143
PSA
49.77
LOGP
5.4848
编号系统
UNII
4HVE799MEJ
物化性质
密度
1.34g/cm3
沸点
514.1ºC at 760mmHg
闪点
264.7ºC
折射率
1.517
蒸汽压
2.16E-11mmHg at 25°C
合成路线
