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前列腺素

前列腺素

CAS号：551-11-1

英文名：prostaglandin F2α

分子式

C20H34O5

熔点

120°C

密度

1.153 g/cm3

分子量

354.481

沸点

531ºC at 760 mmHg

溶解度

信号词

危险品标志

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化合物简介

前列腺素 F2α (在前列腺素的命名中为PGF2α)，其药学上称为地诺前列素(INN)，它在医学上的用途是作为天然的前列腺素用于引产和堕胎药。在哺乳动物中，它是由子宫受刺激时产生的，因为卵泡期并没有受精卵存在，子宫产生PGF2a。他作用于黄体导致黄体退化，形成了纤维化的卵巢白体。PGF2α的作动是根据黄体模受体0的数目而进行。该 PGF2α 亚型8-异前列腺素F2α被发现在子宫内膜异位症患者有显卓的增加，因而是一种与子宫内膜异位相关的氧化应激潜在因子。

基本信息

中文名称

前列腺素

英文名称

prostaglandin F2α

中文别名

前列腺素F2α、前列腺素F2A、地诺前列素

英文别名

glandin、enzaprost、panacelan、dinolytic、DINOPROST、(Z)-7-[(1R,2R,3R,5S)-3,5-dihydroxy-2-((S)-(E)-3-hydroxyoct-1-enyl)-cyclopentyl]hept-5-enoic acid、Prostaglandin F2α、[3H]-PGF2alpha、PGF2ALPHA、cyclosin、Glandin N、Dinprost、Prostaglandin F2a、prostaglandin F2alpha

CAS号

551-11-1

分子式

C20H34O5

分子量

354.481

精确质量

354.241

PSA

97.99

LOGP

3.0429

编号系统

UNII

B7IN85G1HY

物化性质

外观与性状

白色至灰白色结晶固体

密度

1.153 g/cm3

沸点

531ºC at 760 mmHg

熔点

120°C

闪点

289ºC

折射率

1.569

稳定性

Stable for 2 yr in light resistant containers at 5-15ºC degrades in 1 wk when exposed to sunlight or in 3 mo at 40ºC stable in light, air, and heat.

储存条件

Store in a tightly closed container.

安全信息

安全说明

S28

危险品运输编码

224

危险类别

1.1A

包装等级

I

生产方法及用途

生产方法

由生物组织与体液中提取而得。

用途

其氨基丁三醇盐为白色易吸湿结晶性粉末,溶于水。可用于引产和足月分娩时助产,妊娠导致的子宫功能性疾病如葡萄胎、宫内死胎,早产等需要中止妊娠者。其氨基丁三醇盐为兽用平滑肌作用药。制剂为注射剂。

合成路线

共找到4条合成路线 >

花生四烯酸

花生四烯酸

前列腺素 D2

前列腺素 D2

前列腺素e

前列腺素

上游原料

共找到111个上游原料 >

ethyl 2-((1R,2R,3R,5S)-2-((R,E)-3-acetoxyoct-1-en-1-yl)-5-((tert-butyldimethylsilyl)oxy)-3-hydroxycyclopentyl)acetate

ethyl 2-((1R,2R,3R,5S)-2-((R,E)-3-acetoxyoct-1-en-1-yl)-5-((tert-butyldimethylsilyl)oxy)-3-hydroxycyclopentyl)acetate

ethyl 2-((1R,2S,5S)-2-((R,Z)-1-acetoxyoct-2-en-1-yl)-5-((tert-butyldimethylsilyl)oxy)-3-oxocyclopentyl)acetate

ethyl 2-((1R,2S,5S)-2-((R,Z)-1-acetoxyoct-2-en-1-yl)-5-((tert-butyldimethylsilyl)oxy)-3-oxocyclopentyl)acetate

methyl (5Z,7E)-8-[(1S,2R)-4,4-dimethyl-3,5-dioxa-2-(2-oxoethyl)cyclohexyl]-5,7-octadienoate

methyl (5Z,7E)-8-[(1S,2R)-4,4-dimethyl-3,5-dioxa-2-(2-oxoethyl)cyclohexyl]-5,7-octadienoate

反-2-辛烯醛

反-2-辛烯醛

(3aR,4R,5R,6a5)-4-[(E,3S)-3-Hydroxy-1-octenyl]perhydrocyclopenta[b]fura n-2,5-diol

(3aR,4R,5R,6a5)-4-[(E,3S)-3-Hydroxy-1-octenyl]perhydrocyclopenta[b]fura n-2,5-diol

(3R,7S)-3,7-bis(benzyloxy)-1,1-dimethoxydodec-4-yn-6-one

(3R,7S)-3,7-bis(benzyloxy)-1,1-dimethoxydodec-4-yn-6-one

下游产品

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13,14-二氢前列腺素f1alpha

13,14-二氢前列腺素f1alpha

地诺前列素甲基酯

地诺前列素甲基酯

(5Z,9alpha,11alpha,13E,15S)-9,11,15-三羟基-前列腺-5,13-二烯-1-酸 1,9-内酯

(5Z,9alpha,11alpha,13E,15S)-9,11,15-三羟基-前列腺-5,13-二烯-1-酸 1,9-内酯

上游原料

ethyl 2-((1R,2R,3R,5S)-2-((R,E)-3-acetoxyoct-1-en-1-yl)-5-((tert-butyldimethylsilyl)oxy)-3-hydroxycyclopentyl)acetate ethyl 2-((1R,2S,5S)-2-((R,Z)-1-acetoxyoct-2-en-1-yl)-5-((tert-butyldimethylsilyl)oxy)-3-oxocyclopentyl)acetate methyl (5Z,7E)-8-[(1S,2R)-4,4-dimethyl-3,5-dioxa-2-(2-oxoethyl)cyclohexyl]-5,7-octadienoate 反-2-辛烯醛 (3aR,4R,5R,6a5)-4-[(E,3S)-3-Hydroxy-1-octenyl]perhydrocyclopenta[b]fura n-2,5-diol (3R,7S)-3,7-bis(benzyloxy)-1,1-dimethoxydodec-4-yn-6-one (Z)-7-((1R,2R,3R,5S)-3-((tert-butyldimethylsilyl)oxy)-2-((S,E)-3-((tert-butyldimethylsilyl)oxy)oct-1-en-1-yl)-5-hydroxycyclopentyl)hept-5-enoic acid ((((3R,4S,7S,E)-1,1-dimethoxy-4-vinyldodec-5-ene-3,7-diyl)bis(oxy))bis(methylene))dibenzene [3aR(3aα,4α,5β,6aα)]-(-)-5-(苯甲酰氧基)六氢-2-氧代-2H-环戊并[b]呋喃-4-甲醛 (3R,7S)-3,7-bis(benzyloxy)-1,1-dimethoxydodec-4-yn-6-ol methyl (5Z,7E)-8-[(1S,2R)-4,4-dimethyl-3,5-dioxa-2-(2-hydroxyethyl)cyclohexyl]-5,7-octadienoate (-)-3-羰基-6-Β -三苯甲基氧-7-Alpha -苯甲酰氧-2-氧杂双环[ 3.3.0 ]辛烷 (3aR,4R,5R,6aS)-5-(tert-butyldimethylsilyloxy)-4-vinylhexahydro-2H-cyclopenta[b]furan-2-one (4R,5S)-4-(2-tert-butyldimethylsilyloxyethyl)-2,2-dimethyl-1,3-dioxa-5-ethenylcyclohexane (1S,5R,6R,7R)-7-(benzoyloxy)-6-vinyl-2-oxabicyclo[3.3.0]octan-3-one (3aR,4R,5R,6aS)-4-((R,E)-3-hydroxyoct-1-en-1-yl)-5-((tetrahydro-2H-pyran-2-yl)oxy)hexahydro-2H-cyclopenta[b]furan-2-one (4R,5R,1'S)-4,5-bis-(1'-hydroxyhex-1'-yl)-2,2-dimethyl-1,3-dioxolane 5-{[二甲基(2-甲基-2-丙基)硅烷基]氧基}-2-氧代六氢-2H-环戊二烯并[b]呋喃-4-甲醛 (Z)-辛-2-烯醛前列腺素 H2 ethyl 2-((1R,2S,5S)-2-((R,E)-1-acetoxyoct-2-en-1-yl)-5-((tert-butyldimethylsilyl)oxy)-3-oxocyclopentyl)acetate (4R,5R)-4,5-bis((S)-1-(benzyloxy)hexyl)-2,2-dimethyl-1,3-dioxolane (2E)-3-[(1S,2R)-2-(2-tert-butyldimethylsilyloxyethyl)-4,4-dimethyl-3,5-dioxacyclohexyl]-2-propen-1-ol (2R,3S)-5-tert-butyldimethylsilyloxy-2,3-epoxypentan-1-ol (S)-tert-butyl-dimethyl(oct-1-en-3-yloxy)silane methyl (5Z,7E)-8-[(1S,2R)-2-(2-tert-butyldimethylsilyloxyethyl)-4,4-dimethyl-3,5-dioxacyclohexyl]-5,7-octadienoate (3aR,4S,5R,6aS)-5-(tert-butyldimethylsilyloxy)-4-(trityloxymethyl)-hexahydrocyclopenta(b)furan-2-one (6S,7S,8S,9S)-6,9-bis(benzyloxy)tetradecane-7,8-diol ethyl 2-((1R,5S)-5-((tert-butyldimethylsilyl)oxy)-3-((triethylsilyl)oxy)cyclopent-2-en-1-yl)acetate (2R)-2-[[(叔丁基)二甲基硅烷基]氧基]科立内酯 (E)-(3R,4S,7S)-3,7-Bis-benzyloxy-4-vinyl-dodec-5-enal (4R,5R)-5-(benzyloxy)-4-((S,E)-3-(benzyloxy)oct-1-en-1-yl)-3a,4,5,6-tetrahydro-3H-cyclopenta[c]isoxazole (3R,7S)-3,7-bis(benzyloxy)-1,1-dimethoxydodec-4-yn-6-ol 花生四烯酸 4-羧丁基三苯基溴化膦科里内酯地诺前列素甲基酯 (Z)-7-[(1r,2r,3r,5s)-5-乙酰氧基-3-羟基-2-((e)-(s)-3-羟基-1-辛烯)-环戊基]-5-庚烯酸甲酯 (3R,E)-1-((3aR,4R,5R,6aS)-2-oxo-5-((tetrahydro-2H-pyran-2-yl)oxy)hexahydro-2H-cyclopenta[b]furan-4-yl)oct-1-en-3-yl acetate methyl (2E)-2-[(1S,2R)-tert-butyldimethylsilyloxyethyl-4,4-dimethyl-3,5-dioxacyclohexyl]2-propenoate (2S,3R)-5-tert-butyldimethylsilyloxy-2-ethenylpentan-1,3-diol (-)-7α-hydroxy-6β-triphenylmethoxymethyl-cis-2-oxabicyclo[3.3.0]octan-3-one ethyl 2-((1R,2R,5S)-2-((R,E)-3-acetoxyoct-1-en-1-yl)-5-((tert-butyldimethylsilyl)oxy)-3-oxocyclopentyl)acetate [(R)-3,3-Dibromo-1-(2,2-dimethoxy-ethyl)-allyloxymethyl]-benzene 5-(tert-butyldimethylsilyloxy)pent-2-en-1-ol (S)-2-benzyloxyheptanal

下游产品

13,14-二氢前列腺素f1alpha 地诺前列素甲基酯 (5Z,9alpha,11alpha,13E,15S)-9,11,15-三羟基-前列腺-5,13-二烯-1-酸 1,9-内酯