化合物简介
Emapunil (AC-5216, XBD-173) is an anxiolytic drug which acts as a selective agonist at the peripheral benzodiazepine receptor, also known as the mitochondrial 18 kDa translocator protein or TSPO. This protein has multiple functions, among which is regulation of steroidogenesis, particularly the production of neuroactive steroids such as allopregnanolone in the brain. In both animal and human trials, emapunil produced fast acting anxiolytic and anti-panic effects, without producing sedation or withdrawal symptoms following cessation of use. Emapunil is also used in its 11C radiolabelled form to map the distribution of TSPO receptors in the brain.
基本信息
中文名称
Emapunil
英文名称
N-benzyl-N-ethyl-2-(7-methyl-8-oxo-2-phenylpurin-9-yl)acetamide
中文别名
英文别名
AC-5216、Emapunil、UNII-OG837L732J
CAS号
226954-04-7
分子式
C23H23N5O2
分子量
401.461
精确质量
401.185
PSA
73.02
LOGP
2.8457
物化性质
密度
1.25g/cm3
沸点
536.2ºC at 760mmHg
闪点
278.1ºC
折射率
1.624
蒸汽压
1.42E-11mmHg at 25°C
安全信息
危险标志
GHS07
危险性描述
H302
危险性防范说明
P301 + P312 + P330
信号词
Warning