化合物简介
(R)-Hydroxy Des(boric acid) Bortezomib is an impurity in the synthesis of Bortezomib, the first proteasome inhibitor to be approved by the US FDA for multiple myeloma, a blood cancer. A reversible inhibitor of the 26S proteasome-a barrel-shaped multiprotein particle found in the nucleus and cytosol of all eukaryotic cells. Targets the ubiquitin-proteasome pathway.
基本信息
中文名称
硼替佐米杂质2
英文名称
N-((S)-1-(((R)-1-hydroxy-3-methylbutyl)amino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide
中文别名
英文别名
(R)-Hydroxy Des(boric Acid) Bortezomib、N-((S)-1-((R)-1-hydroxy-3-methylbutylamino)-1-oxo-3-phenylpropan-2-yl)pyrazine-2-carboxamide、(N-[(1R)-1-hydroxy-3-methylbutyl]-NAlpha-(pyrazin-2-ylcarbonyl)-L-phenylalaninamide、BORTEZOMIB IMPURITY 2 (SR-ISOMER, EP IMPURITY E)
CAS号
289472-78-2
分子式
C19H24N4O3
分子量
356.419
精确质量
356.185
PSA
104.21
LOGP
2.0802
安全信息
海关编码
2934999090
