化合物简介
SB-269970 is a drug and research chemical developed by GlaxoSmithKline used in scientific studies. It is believed to act as a selective 5-HT7 receptor antagonist (EC50 = 1.25 nM) (or possibly inverse agonist). A subsequent study in guinea pig at 10 uM showed that it also blocks the α2-adrenergic receptor activity. The significant difference in test concentrations, however, confirms the selectivity of SB-269970 for the 5-HT7 receptor.
基本信息
中文名称
SB 269970盐酸盐
英文名称
SB 269970 hydrochloride,(2R)-1-[(3-Hydroxyphenyl)sulfonyl]-2-[2-(4-methyl-1-piperidinyl)ethyl]pyrrolidinehydrochloride
中文别名
英文别名
CAS号
201038-74-6
分子式
C18H29ClN2O3S
分子量
388.952
精确质量
388.159
PSA
69.23
LOGP
4.4259
编号系统
BRN号
24278708
MDL号
MFCD03788020
物化性质
沸点
512.9ºC at 760 mmHg
闪点
264ºC
蒸汽压
3.87E-11mmHg at 25°C
