化合物简介
Tasimelteon (trade name Hetlioz) is a drug approved by the U.S. Food and Drug Administration (FDA) in January 2014 for the treatment of non-24-hour sleep–wake disorder (also called Non-24, N24 and N24HSWD). In June 2014, the European Medicines Agency accepted an EU filing application for tasimelteon and in July 2015, the drug was approved in Europe for the treatment of non-24-hour sleep-wake rhythm disorder in totally blind adults, but not in the rarer case of non-24 in sighted people.
基本信息
中文名称
他司美琼
英文名称
tasimelteon
中文别名
(1R-TRANS)-N-[[2-(2,3-二氢-4-苯并呋喃基)环丙基]甲基]丙酰胺
英文别名
Tasimelteon、UNII-SHS4PU80D9、VEC-162、Hetlioz、MA 1、N-[[(1R,2R)-2-(2,3-dihydro-1-benzofuran-4-yl)cyclopropyl]methyl]propanamide
CAS号
609799-22-6
分子式
C15H19NO2
分子量
245.317
精确质量
245.142
PSA
38.33
LOGP
2.6421
编号系统
EINECS号
612-059-5
物化性质
密度
1.145
沸点
442.553ºC at 760 mmHg
闪点
221.448ºC
折射率
1.564