化合物简介
KRN 633 is an ATP-competitive inhibitor of vascular endothlial growth factor receptor tyrosine kinase (VEGFR). KRN 633 also suppresses VEGF-dependent activation of MAPK and cell proliferation and demonstrates antitumor and antiangiogenic activity by inhibiting vessel formation and vascular permeability in human tumor xenograft models.
基本信息
中文名称
KRN 633; N-[2-氯-4-[(6,7-二甲氧基-4-喹唑啉基)氧基]苯基]-N'-丙基脲
英文名称
1-[2-chloro-4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-3-propylurea
中文别名
英文别名
KRN633,KRN-633,KRN 633、1-(2-chloro-4-(6,7-dimethoxyquinazolin-4-yloxy)phenyl)-3-propylurea、KRN633、N-{2-chloro-4-[(6,7-dimethoxy-4-quinazolinyl)oxy]phenyl}-N\'-propylurea、VEGF Receptor Tyrosine Kinase Inhibitor III,KRN633
CAS号
286370-15-8
分子式
C20H21ClN4O4
分子量
416.858
精确质量
416.125
PSA
98.09
LOGP
4.9016
编号系统
MDL号
MFCD14155620
合成路线
