化合物简介
URB602 ([1,1'-biphenyl]-3-yl-carbamic acid, cyclohexyl ester) is a compound that has been found to inhibit hydrolysis of monoacyl glycerol compounds, such as 2-arachidonoylglycerol (2-AG) and 2-oleoylglycerol (2-OG). It was first described in 2003. A study performed in 2005 found that the compound had specificity for metabolizing 2-AG over anandamide (another cannabinoid ligand) in rat brain presumably by inhibiting the enzyme monoacylglycerol lipase (MAGL), which is the primary metabolic enzyme of 2-AG. However, subsequent studies have shown that URB602 lacks specificity for MAGL inhibition in vitro.
基本信息
中文名称
3-(环已氧羰基胺基)联苯
英文名称
cyclohexyl N-(3-phenylphenyl)carbamate
中文别名
[1,1-联苯]-3-氨基甲酸环己酯
英文别名
N-Biphenyl-3-ylcarbamic acid,cyclohexyl ester、Monoacylglycerol Lipase Inhibitor,URB602、Biphenyl-3-yl Carbamic Acid,Cyclohexyl Ester、cyclohexyl ester、URB602、cyclohexyl biphenyl-3-ylcarbamate
CAS号
565460-15-3
分子式
C19H21NO2
分子量
295.376
精确质量
295.157
PSA
38.33
LOGP
5.3078
编号系统
MDL号
MFCD08457914
物化性质
外观与性状
灰白色固体
密度
1.149g/cm3
沸点
416.611ºC at 760 mmHg
熔点
122-123ºC
闪点
205.759ºC
折射率
1.595
安全信息
海关编码
2924299090