化合物简介
Labelled Isoniazid. Antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis. Metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins. Selectively induces expression of CYP2E1. Reversibly inhibits CYP2C19 and CYP3A4 activities, and mechanistically inactivates CYP1A2, CYP2A6, CYP2C19 and CYP3A4 at clinically relevant concentrations. Antibacterial (tuberculostatic).
基本信息
中文名称
异烟肼-D4
英文名称
Isoniazid-d4
中文别名
氘代异烟肼-d4、异烟肼-d4
英文别名
Sauterazid-d4、Isonizide-d4、Isotebezid-d4、Armazid-d4、Zonazide-d4、Robisellin-d4、Armazide-d4、Atcotibine-d4
CAS号
774596-24-6
分子式
C6H3D4N3O
分子量
141.164
精确质量
141.084
PSA
68.01
LOGP
0.7763
物化性质
密度
1.281g/cm3
熔点
171.4ºC
折射率
1.584
储存条件
Refrigerator
