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3-{[3-乙酰氨基-5-羟基-6-(羟基甲基)-4-{[3,4,5-三羟基-6-(羟基甲基)四氢-2H-吡喃-2-基]氧基}四氢-2H-吡喃-2-基]氧基}-2-氨基丁酸

3-{[3-乙酰氨基-5-羟基-6-(羟基甲基)-4-{[3,4,5-三羟基-6-(羟基甲基)四氢-2H-吡喃-2-基]氧基}四氢-2H-吡喃-2-基]氧基}-2-氨基丁酸

CAS号：60280-58-2

英文名：Gal β(1-3)GalNAc-α-Thr

分子式

C18H32N2O13

熔点

>170ºC(dec.)

密度

1.587g/cm3

分子量

484.452

沸点

872.474ºC at 760 mmHg

溶解度

信号词

危险品标志

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化合物简介

A cancer associated carbohydrate tumor antigen which may be effective as cancer specific targets for immunotherapy as well as in the development of diagnostic monoclonal antibodies. Has been used or considered for use in human vaccines.

基本信息

中文名称

3-{[3-乙酰氨基-5-羟基-6-(羟基甲基)-4-{[3,4,5-三羟基-6-(羟基甲基)四氢-2H-吡喃-2-基]氧基}四氢-2H-吡喃-2-基]氧基}-2-氨基丁酸

英文名称

Gal β(1-3)GalNAc-α-Thr

中文别名

GALΒ(1-3)GALNAC-Α-THR

英文别名

T Epitope, Threonyl

CAS号

60280-58-2

分子式

C18H32N2O13

分子量

484.452

精确质量

484.19

PSA

250.72

LOGP

-4.9032

物化性质

密度

1.587g/cm3

沸点

872.474ºC at 760 mmHg

熔点

>170ºC(dec.)

闪点

481.455ºC

折射率

1.613

储存条件

-20ºC Freezer, Under Inert Atmosphere

合成路线

O-((2,3,4,6-Tetra-O-acetyl-β-D-galactopyranosyl)-(1-->3)-O-(2-acetamido-4,6-di-O-benzoyl-2-desoxy-α-D-galactopyranosyl))-L-threonin

O-((2,3,4,6-Tetra-O-acetyl-β-D-galactopyranosyl)-(1-->3)-O-(2-acetamido-4,6-di-O-benzoyl-2-desoxy-α-D-galactopyranosyl))-L-threonin

3-{[3-乙酰氨基-5-羟基-6-(羟基甲基)-4-{[3,4,5-三羟基-6-(羟基甲基)四氢-2H-吡喃-2-基]氧基}四氢-2H-吡喃-2-基]氧基}-2-氨基丁酸

3-{[3-乙酰氨基-5-羟基-6-(羟基甲基)-4-{[3,4,5-三羟基-6-(羟基甲基)四氢-2H-吡喃-2-基]氧基}四氢-2H-吡喃-2-基]氧基}-2-氨基丁酸

上游原料

共找到16个上游原料 >

3-O-(2-Acetamido-3,4,6-tri-O-acetyl-2-desoxy-α-D-galactopyranosyl)-N-(benzyloxycarbonyl)-L-threoninbenzylester

3-O-(2-Acetamido-3,4,6-tri-O-acetyl-2-desoxy-α-D-galactopyranosyl)-N-(benzyloxycarbonyl)-L-threoninbenzylester

N-(Benzyloxycarbonyl)-3-O-(3,4,6-tri-O-acetyl-2-azido-2-desoxy-α-D-galactopyranosyl)-L-threoninbenzylester

N-(Benzyloxycarbonyl)-3-O-(3,4,6-tri-O-acetyl-2-azido-2-desoxy-α-D-galactopyranosyl)-L-threoninbenzylester

O-(2,3,4,6-Tetra-O-acetyl-β-D-galactopyranosyl)-(1[*]3)-O-(2-acetamido-4,6-O-benzyliden-2-desoxy-α-D-galactopyranosyl)-(1[*]3)-N-(benzyloxycarbonyl)-L-threoninbenzylester

O-(2,3,4,6-Tetra-O-acetyl-β-D-galactopyranosyl)-(1[*]3)-O-(2-acetamido-4,6-O-benzyliden-2-desoxy-α-D-galactopyranosyl)-(1[*]3)-N-(benzyloxycarbonyl)-L-threoninbenzylester

3,4,6-tri-O-acetyl-2-azido-2-deoxy-β-D-galactopyranosyl chloride

3,4,6-tri-O-acetyl-2-azido-2-deoxy-β-D-galactopyranosyl chloride

3-O-(2-Acetamido-2-desoxy-α-D-galactopyranosyl)-N-(benzyloxycarbonyl)-L-threoninbenzylester

3-O-(2-Acetamido-2-desoxy-α-D-galactopyranosyl)-N-(benzyloxycarbonyl)-L-threoninbenzylester

1-Acetyl-2-azido-4,6-di-O-benzoyl-2-desoxy-3-O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-O-α-D-galactopyranose

1-Acetyl-2-azido-4,6-di-O-benzoyl-2-desoxy-3-O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-O-α-D-galactopyranose

上游原料

3-O-(2-Acetamido-3,4,6-tri-O-acetyl-2-desoxy-α-D-galactopyranosyl)-N-(benzyloxycarbonyl)-L-threoninbenzylester N-(Benzyloxycarbonyl)-3-O-(3,4,6-tri-O-acetyl-2-azido-2-desoxy-α-D-galactopyranosyl)-L-threoninbenzylester O-(2,3,4,6-Tetra-O-acetyl-β-D-galactopyranosyl)-(1[*]3)-O-(2-acetamido-4,6-O-benzyliden-2-desoxy-α-D-galactopyranosyl)-(1[*]3)-N-(benzyloxycarbonyl)-L-threoninbenzylester 3,4,6-tri-O-acetyl-2-azido-2-deoxy-β-D-galactopyranosyl chloride 3-O-(2-Acetamido-2-desoxy-α-D-galactopyranosyl)-N-(benzyloxycarbonyl)-L-threoninbenzylester 1-Acetyl-2-azido-4,6-di-O-benzoyl-2-desoxy-3-O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-O-α-D-galactopyranose 3-O-(2-Acetamido-4,6-O-benzyliden-2-desoxy-α-D-galactopyranosyl)-N-(benzyloxycarbonyl)-L-threoninbenzylester O-(2,3,4,6-Tetra-O-acetyl-β-D-galactopyranosyl)-(1[*]3)-O-(2-acetamido-2-desoxy-α-D-galactopyranosyl)-(1[*]3)-L-threonin O-((2,3,4,6-Tetra-O-acetyl-β-D-galactopyranosyl)-(1-->3)-O-(2-acetamido-4,6-di-O-benzoyl-2-desoxy-α-D-galactopyranosyl))-L-threonin 2-azido-4,6-di-O-benzoyl-2-deoxy-3-O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-α-D-galactopyranosyl bromide L-苏氨酸 3-O-<2-Acetamido-4,6-di-O-benzoyl-2-desoxy-3-O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-α-D-galactopyranosyl>-N-benzyloxycarbonyl-L-threoninbenzylester GalNAcα1-O-Thr 对硝基苯基-β-D-吡喃半乳糖苷(PNPG) O-(2,3,4,6-tetra-O-acetyl-β-D-galactopyranosyl)-(1->3)-O-(2-acetamido-4,6-di-O-acetyl-2-deoxy-α-D-galactopyranosyl)-(1->3)-N-(benzyloxycarbonyl)-L-threonine tert-butyl ester 对硝基苯-T抗原