化合物简介
A potent O-GlcNAcase inhibitor that blocks phosphorylation of tau in vivo. The authors anticipate that Thiamet-G will find wide use in probing the functional role of O-GlcNAc in vertebrate brain, and it may also offer a route to blocking pathological hyperphosphorylation of tau in AD. Anti-Alzheimer's agent.
基本信息
中文名称
Thiamet G
英文名称
2-(ethylamino)-5-(hydroxymethyl)-5,6,7,7a-tetrahydro-3aH-pyrano[3,2-d][1,3]thiazole-6,7-diol
中文别名
英文别名
Thiamet G0nDiscontinued、Thiamet G
CAS号
1009816-48-1
分子式
C9H16N2O4S
分子量
248.299
精确质量
248.083
PSA
119.61
LOGP
-1.6672
