化合物简介
(2S)-2-(4-Chlorophenyl)-1-[4-[(5R,7R)-6,7-dihydro-7-hydroxy-5-methyl-5H-cyclopentapyrimidin-4-yl]-1-piperazinyl]-3-[(1-methylethyl)amino]-1-propanone is a highly selective AKT inhibitor targeting Akt1, Akt2 and Akt3. Studies have shown its use in combination with vemurafenib, have demonstrated therapeutic value in the treatment of hyperproliferative disorders such as cancer.
基本信息
中文名称
Ipatasertib
英文名称
Ipatasertib
中文别名
英文别名
RG 7440、GDC-0068、(2S)-2-(4-chlorophenyl)-1-[4-[(5R,7R)-7-hydroxy-5-methyl-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-yl]piperazin-1-yl]-3-(propan-2-ylamino)propan-1-one
CAS号
1001264-89-6
分子式
C24H32ClN5O2
分子量
457.996
精确质量
457.224
PSA
81.59
LOGP
3.4948
编号系统
MDL号
MFCD22124514
