化合物简介
Aldophosphamide semicarbazone is a major metabolite of cyclophosphamide, a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity.
基本信息
中文名称
羟基环磷酰胺缩氨基脲
英文名称
[(E)-3-[amino-[bis(2-chloroethyl)amino]phosphoryl]oxypropylideneamino]urea
中文别名
英文别名
Hydroxy cyclophosphamide Semicarbazone
CAS号
53948-46-2
分子式
C8H18Cl2N5O3P
分子量
334.14
精确质量
333.052
PSA
132.85
LOGP
2.6851
物化性质
密度
1.55g/cm3
折射率
1.587
