化合物简介
Kasugamycin (Ksg) is an aminoglycoside antibiotic that was originally isolated in 1965, from Streptomyces kasugaensis, a Streptomyces strain found near the Kasuga shrine in Nara, Japan. Kasugamycin was discovered by Hamao Umezawa, who also discovered kanamycin and bleomycin, as a drug which could prevent growth of a fungus causing rice blast disease. It was later found to inhibit bacterial growth also. It exists as a white, crystalline substance with the chemical formula C14H28ClN3O10 (kasugamycin hydrochloride). It is also known as kasumin.
基本信息
中文名称
春雷霉素盐酸盐
英文名称
kasugamycin hydrochloride
中文别名
盐酸春雷霉素
英文别名
kasugamycin,monohydrochloride、KASUGAMYCIN HYDROCHL、kasugamycin (jmaff)、Kasugamycin hydrochloride、KasugaMycin HCl、3-O-[2-amino-4-[(carboxyiminomethyl)amino]-2,3,4,6-tetradeoxy-α-D-arabino-hexopyranosyl]-D-chiro-inositol monohydrochloride、Kasugamycin hydrochloride from Streptomyces kasugaensis、KASUGAMYCIN HYDROCHLORIDE HYDRATE、[5-amino-2-methyl-6-(2,3,4,5,6-pentahydroxycyclohexyloxy)tetrahydropyran-3-yl]amino-α-iminoacetic acid hydrochloride、kasumin、3-o-[2-amino-4-[(carboxyiminomethyl)amino]-2,3,4,6-tetradeoxy-d-arabino-hexopyranosyl]-d-chiro-inositol、KASUGAMYCIN HCL HYDRATE、1L-1,3,4/2,5,6-1-deoxy-2,3,4,5,6-pentahydroxycyclohexyl 2-amino-2,3,4,6-tetradeoxy-4-(α-iminoglycino)-α-D-arabino-hexopyranoside hydrochloride
CAS号
19408-46-9
分子式
C14H26ClN3O9
分子量
415.824
精确质量
415.136
PSA
218.81
LOGP
-2.3351
编号系统
UNII
SXA18D440T
物化性质
密度
1.97g/cm3
沸点
628.2ºC at 760mmHg
熔点
203ºC (dec)
闪点
333.7ºC
折射率
1.738
储存条件
库房通风低温干燥,与食品原料分开储运
蒸汽压
2.04E-18mmHg at 25°C
安全信息
安全说明
S22; S24/25; S26
生产方法及用途
用途
春雷霉素是农用抗生素，具有很强的内吸渗透性，具有预防和治疗双重作用。
