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阿维菌素

阿维菌素

CAS号:65195-55-3
英文名:avermectin B1a
分子式:C48H72O14
分子量:873.077
上游原料
4'',5,7-tris[O-(trimethylsilyl)]-Δ2-4(R)-avermectin B1a <2S(2R,4E,6S,7S)>-2-<2-(tert-butyldimethylsilyloxy)-6-(tert-butyldiphenylsilyloxy)-5,7-dimethylnona-4,8-dienyl>oxirane <2R(2E,4S,5S),4S,6S,8R(S),9S>-2-<4-hydroxy-3,5-dimethylhepta-2,6-dienyl>-9-methyl-8-(1-methypropyl)-1,7-dioxaspiro<5.5>undec-10-en-4-ol (2S,3S,E)-6-((2R,4S,6S,8R,9S)-8-((S)-sec-butyl)-4-((tert-butyldimethylsilyl)oxy)-9-methyl-1,7-dioxaspiro[5.5]undec-10-en-2-yl)-3-((tert-butyldimethylsilyl)oxy)-2,4-dimethylhex-4-en-1-ol (1S,2S,3S,5S,6S)-3-[(tert-butyldiphenylsilyloxy)methyl]-5-methyl-2-[1-methylene-3-(phenylsulphonyl)propyl]-7-oxabicyclo[4.1.0]heptan-2-ol 4'',5-bis<O-(dimethyl-tert-butylsilyl)>-2-epiavermectin B1a (1E,3S,4S)-1-bromo-2,4-dimethylhexa-1,5-dien-3-ol (1S,2S,3R,4S,6S)-6-[(tert-butyldiphenylsilyloxy)methyl]-4-methyl-1-[1-methylene-3-(phenylsulphonyl)propyl]cyclohexane-1,2,3-triol (3E<2E,4S,5S,6E,8<2R,4S,6S,8R(S),9S>>,3aS,4S,6S,7R,7aR)-octahydro-3a,7-dihydroxy-3-<5-hydroxy-8-<4-hydroxy-9-methyl-8-(1-methylpropyl)-1,7-dioxaspiro<5.5>undec-10-en-2-yl>-4,6-dimethylocta-2,6-dienylidene>-6-methylbenzofuran-4-carbaldehyde (3S,4R,5S)-3,5-dimethylhept-1-yn-4-ol (3S,4S)-4-methylhexane-1,3-diol (1S,2R,3R,4S,6S)-3-(tert-butyldimethylsilyloxy)-6-[(tert-butyldiphenylsilyloxy)methyl]-4-methyl-1-[1-methylene-3-(phenylsulphonyl)propyl]cyclohexane-1,2-diol (1S,4S,6S)-6-[(tert-butyldiphenylsilyloxy)methyl]-4-methyl-1-[1-methylene-3-(phenylthio)propyl]cyclohex-2-enol (1S,3S,5S,6S)-3-((tert-butyldiphenylsilyloxy)methyl)-5-methyl-7-oxabicyclo(4.1.0)heptan-2-one (3E<2E,4S,5S,6E,8<2R,4S,6S,8R(S),9S>>,3aS,4S,6S,7R,7aR)-octahydro-3a,7-dihydroxy-3-<5-hydroxy-8-<4-hydroxy-9-methylpropyl)-1,7-dioxaspiro<5.5>undec-10-en-2-yl>-4,6-dimethylocta-2,6-dienylidene>-6-methylbenzofuran-4-carboxylic acid (2R,3R,4S)-3-(methoxymethoxy)-2,4-dimethylhexanal (4S)-5-dehydroxy-3,4-dihydro-5-oxoavermectin B1a aglycone (1S,2S,3R,4S,6S)-3-(tert-butyldimethylsilyloxy)-6-((tert-butyldiphenylsilyloxy)methyl)-4-methyl-1-(1-methylene-3-(phenylsulphonyl)propyl)cyclohexane-1,2-diol 5,4''-bis-O-(tert-butyldimethylsilyl)avermectin B2a (1S,2S,3S,5S,6S)-3-((tert-butyldiphenylsilyloxy)methyl)-5-methyl-2-(1-methylene-3-(phenylthio)propyl)-7-oxabicyclo(4.1.0)heptan-2-ol Δ2-4(R)-avermectin B1a 4'',5-bis<O-(dimethyl-tert-butylsilyl)>-Δ2-4(R)-avermectin B1a 2-((2R,4S,6S,8R,9S)-4-(benzyloxy)-8-((S)-sec-butyl)-9-methyl-1,7-dioxaspiro[5.5]undec-10-en-2-yl)ethan-1-ol [1R(S),2R,3R,4S,6S]-3-(tert-butyldimethylsilyloxy)-6-[(tert-butyldiphenylsilyloxy)methyl]-1-[1-hydroxymethyl-3-(phenylsulphonyl)propyl]-4-methylcyclohexane-1,2-diol [2R(2E,4S,5S),4S,6S,8R(S),9S]-4-(tert-butyldimethylsilyloxy)-2-[4-(tert-butyldimethylsilyloxy)-3,5-dimethylhepta-2,6-dienyl]-9-methyl-8-(1-methypropyl)-1,7-dioxaspiro[5.5]undec-10-en-4-ol <2S,3S,4E,6<2R,4S,6S,8R(S),9S>>-3-(tert-butyldimethylsilyloxy)-6-<4-(tert-butyldimethylsilyloxy)-9-methyl-8-(1-methypropyl)-1,7-dioxaspiro<5.5>undec-10-en-2-yl>-2,4-dimethylhex-4-enal O-(4-O-L-oleandrosyl-L-oleandrosyl)imidazole-1-thiocarboxylate 5,4''-bis-O-(tert-butyldimethylsilyl)-23-O-(methanesulfonyl)avermectin B2a 阿维菌素 (1E,3S,4S)-1-bromo-3-(tert-butyldiphenylsilyloxy)-2,4-dimethylhexa-1,5-diene (1S,4S,6S)-6-[(tert-butyldiphenylsilyloxy)methyl]-4-methyl-1-[1-methylene-3-(phenylsulphonyl)propyl]cyclohex-2-enol [2RS,3S,4S,5E,7[2R,4S,6S,8R(S),9S]]-4-(tert-butyldimethylsilyloxy)-7-[4-(tert-butyldimethylsilyloxy)-9-methyl-8-(1-methypropyl)-1,7-dioxaspiro[5.5]undec-10-en-2-yl]-3,5-dimethylhept-5-ene-1,2-diol methyl (3aR,6S,7R,7aR,E)-3-((2E,4S,5S,6E)-8-((2R,4S,6S,8R,9S)-8-((S)-sec-butyl)-4-hydroxy-9-methyl-1,7-dioxaspiro[5.5]undec-10-en-2-yl)-5-hydroxy-4,6-dimethylocta-2,6-dien-1-ylidene)-3a,7-dihydroxy-6-methyl-2,3,3a,6,7,7a-hexahydrobenzofuran-4-carboxylate (((3S,4R,5S)-3,5-dimethylhept-1-yn-4-yl)oxy)trimethylsilane (2S,3S,5S,6R)-6-(tert-butyldimethylsilyloxy)-3-[(tert-butyldiphenylsilyloxy)methyl]-2-hydroxy-5-methyl-2-[1-methylene-3-(phenylsulphonyl)propyl]cyclohexanone 4'',5-di-O-tert-butyldimethylsilyl-22,23-dihydroavermectin B1 (4S)-3,4-dihydroavermectin B1a aglycone 4'',5,7-tris-O-trimethylsilyl-avermectin B1 (3S,4R,5S)-4-(methoxymethoxy)-3,5-dimethylhept-1-yne avermectin B1a aglycon 5-tert-butyldimethylsilyl ether avermectin B1a aglycone (3E<2E,4S,5S,6E,8<2R,4S,6S,8R(S),9S>>,3aS,4S,6S,7R,7aR)-octahydro-4-(hydroxymethyl)-3-<5-hydroxy-8-<4-hydroxy-9-methyl-8-(1-methylpropyl)-1,7-dioxaspiro<5.5>undec-10-en-2-yl>-4,6-dimethylocta-2,6-dienylidene>-6-methylbenzofuran-3a,7-diol 4'',5-bis(O-(dimethyl-tert-butylsilyl))-7-O-(trimethylsilyl)-Δ2-4(R)-avermectin B1a (1S,2S,3R,4S,6S)-6-(hydroxymethyl)-4-methyl-1-(1-methylene-3-(phenylsulphonyl)propyl)cyclohexane-1,2,3-triol (4S,6S)-6-<(tert-butyldiphenylsilyloxy)methyl>-4-methylcyclohex-2-enone (2S,3R,4S)-2,4-dimethyl-1,3-hexanediol