化合物简介
A farnesyltransferase inhibitor. Sensitizes human multiple myeloma cell to proteasome inhibition by blocking degradation of bortezomib(B675700)-induced aggresomes. Also shown to inhibit the growth of myeloid leukemia cell lines and primary leukemia cells by inducing apoptosis and cell-cycle blockage when combined with rapamycin(R124000).
基本信息
中文名称
替吡法尼
英文名称
6-[(R)-amino-(4-chlorophenyl)-(3-methylimidazol-4-yl)methyl]-4-(3-chlorophenyl)-1-methylquinolin-2-one
中文别名
(R)-6-(氨基(4-氯苯基)(1-甲基-1H-咪唑-5-基)甲基)-4-(3-氯苯基)-1-甲基-2(1H)-喹啉酮
英文别名
Tipifarnib (Zarnestra)、Zarnestra、Tipifarnib
CAS号
192185-72-1
分子式
C27H22Cl2N4O
分子量
489.396
精确质量
488.117
PSA
65.84
LOGP
6.1967
编号系统
UNII
MAT637500A
物化性质
外观与性状
灰白色至淡米色固体
密度
1.33g/cm3
沸点
681.7ºC at 760mmHg
熔点
211-213ºC (dec.)
闪点
366.1ºC
折射率
1.671
蒸汽压
1.94E-18mmHg at 25°C
