化合物简介
JNJ-770662 is a broad spectrum inhibitor of cyclin-dependent kinases and aurora kinases including CDK1/Cyclin B, CDK2/Cyclin A, CDK2/Cyclin E, Aurora-A and Aurora-B. JNJ-770662 has been shown to induce growth suppression and mitotic defects, these results suggest that JNJ-7706621 could be useful for cell cycle analysis and therapy of various cancers, including Ewing's sarcoma.
基本信息
中文名称
JNJ-7706621
英文名称
JNJ-7706621
中文别名
4-[[5-氨基-1-(2,6-二氟苯甲酰基)-1H-1,2,4-三唑-3-基]氨基]苯磺酰胺
英文别名
4-[[5-Amino-1-(2,6-difluorobenzoyl)-1,2,4-triazol-3-yl]amino]benzenesulfonamide
CAS号
443797-96-4
分子式
C15H12F2N6O3S
分子量
394.356
精确质量
394.066
PSA
154.37
LOGP
3.6533
编号系统
MDL号
MFCD11100270
物化性质
密度
1.71
沸点
676.6ºC at 760 mmHg
熔点
149-155ºC
闪点
363ºC
安全信息
海关编码
2935009090
上游原料
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