4-[4-[[5-(4,5-二甲基-2-硝基苯基)-2-呋喃基]亚甲基]-4,5-二氢-3-甲基-5-氧代-1H-吡唑-1-基]-苯甲酸

C646 is an inhibitor for histone acetyltransferase p300 and may be a potential candidate for treating AML1-ETO \n(AE) positive acute myeloid leukemia (AML). It is shown that C646 inhibited cellular proliferation, reduced colony formation, evoked partial cell cycle arrest in the G1 phase, and induced apoptosis in AE-positive AML cell lines and primary blasts isolated from leukemic mice and AML patients.