化合物简介
CPHPC (R-1-[6-[R-2-carboxy-pyrrolidin-1-yl]-6-oxo-hexanoyl] pyrrolidine-2-carboxylic acid) is a proline-derived small molecule able to strip amyloid P (AP) from deposits by reducing levels of circulating serum amyloid P (SAP). The SAP-amyloid association has also been identified as a possible drug target for anti-amyloid therapy, with the recent development and first stage clinical trials of CPHPC for amyloidosis.
基本信息
中文名称
(2R)-1-[6-[(2R)-2-carboxypyrrolidin-1-yl]-6-oxohexanoyl]pyrrolidine-2-carboxylic acid
英文名称
(2R)-1-[6-[(2R)-2-carboxypyrrolidin-1-yl]-6-oxohexanoyl]pyrrolidine-2-carboxylic acid
中文别名
英文别名
CPOHPC acid、GHE、cphpc、(2r)-1-[6-[(2r)-2-Carboxypyrrolidin-1-Yl]-6-Oxidanylidene-Hexanoyl]pyrrolidine-2-Carboxylic Acid、Ro 63-8695
CAS号
224624-80-0
分子式
C16H24N2O6
分子量
340.372
精确质量
340.163
PSA
115.22
LOGP
0.5738
编号系统
UNII
WO97N24A47
物化性质
蒸汽压
1.13E-19mmHg at 25°C