化合物简介
U46619 is a stable synthetic analog of the endoperoxide prostaglandin PGH2 first prepared in 1975, and acts as a thromboxane A2 (TP) receptor agonist. It potently stimulates TP receptor-mediated, but not other prostaglandin receptor-mediated responses in various in vitro preparations. and exhibits many properties similar to thromboxane A2, including shape change and aggregation of platelets and smooth muscle contraction. U46619 is a vasoconstrictor that mimics the hydroosmotic effect of vasopressin.
基本信息
中文名称
9,11-二脱氧基-9α,11α-亚甲基环氧前列腺素 F2α溶液
英文名称
9,11-Dideoxy-11α,9α-epoxymethanoprostaglandin F2α
中文别名
英文别名
U 46619,(5Z)-7-[(1R,4S,5S,6R)-6-[(1E,3S)-3-Hydroxy-1-octenyl]-2-oxabicyclo[2.2.1]hept-5-yl]-5-heptenoicacid
CAS号
56985-40-1
分子式
C21H34O4
分子量
350.492
精确质量
350.246
PSA
66.76
LOGP
4.3361
编号系统
MDL号
MFCD00135238
BRN号
4267334
PubChem号
24894197
物化性质
密度
1.092g/cm3
沸点
519.7ºC at 760 mmHg
闪点
176.1ºC
折射率
1.547