化合物简介
Maraviroc (brand-named Selzentry, or Celsentri outside the U.S.) is an antiretroviral drug in the CCR5 receptor antagonist class used in the treatment of HIV infection. It is also classed as an entry inhibitor. It also appeared to reduce graft-versus-host disease in patients treated with allogeneic bone marrow transplantation for leukemia, in a phase 1/2 study.
基本信息
中文名称
马拉韦罗
英文名称
Maraviroc
中文别名
马拉韦罗、马拉韦若、4,4-二氟-N-[(1S)-3-[(1R,5S)-3-(3-甲基-5-异丙基-1,2,4-三唑-4-基)-8-氮杂双环[3.2.1]辛烷-8-基]-1-苯基丙基]环己烷-1-甲酰胺
英文别名
Selzentry、Celsentri、maroviroc、4,4-Difluoro-N-[(1S)-3-{(1R,3s,5S)-3-[3-methyl-5-(propan-2-yl)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]octan-8-yl}-1-phenylpropyl]cyclohexanecarboxamide、4,4-difluoro-N-((S)-3-((1R,3S,5S)-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octan-8-yl)-1-phenylpropyl)cyclohexane-1-carboxamide、4,4-Difluoro-N-[(1S)-3-[(3-exo)-3-[3-methyl-5-(1-methylethyl-d6)-4H-1,2,4-triazol-4-yl]-8-azabicyclo[3.2.1]oct-8-yl]-1-phenylpropyl]cyclohexanecarboxamide、UK 427857
CAS号
376348-65-1
分子式
C29H41F2N5O
分子量
513.666
精确质量
513.328
PSA
63.05
LOGP
6.2797
编号系统
UNII
MD6P741W8A
物化性质
外观与性状
棕色固体
密度
1.29 g/cm3
熔点
79-81ºC
折射率
1.627
安全信息
海关编码
2934999090
合成路线
