合成路线
117020-90-3
116996-31-7
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洛伐他汀
CAS号：75330-75-5
英文名：lovastatin
分子式：C24H36O5
分子量：404.54
上游原料
4-(叔丁基二甲基甲硅烷氧基)-6-[2-(8-羟基-2,6-二甲基-1,2,6,7,8,8a-六氢萘)-乙基]-四氢吡喃-2-酮
<4S-<4α,5α(4S*,6R*),6β(1R*,3S*)>>-5-<2-<6-<2-<<(1,1-dimethylethyl)diphenylsilyl>oxy>ethyl>-2,2-dimethyl-1,3-dioxan-4-yl>ethyl>-4-methyl-6-<3-methyl-1-<(triethylsilyl)oxy>-4-pentenyl>-2-cyclohexen-1-one
洛伐他汀钠
<4R-<4α(4R*,5R*),6α>>-5-<2-<6-<2-<<(1,1-dimethylethyl)diphenylsilyl>oxy>ethyl>-2,2-dimethyl-1,3-dioxan-4-yl>ethyl>-4-methyl-2-cyclohexen-1-one
2-methyl-butyric acid 8-{2-[4-(tert-butyl-dimethyl-silanyloxy)-6-oxo-tetrahydro-pyran-2-yl]-ethyl}-7-methyl-6-oxo-1,2,6,7,8,8a-hexahydro-naphthalen-1-yl ester
(S)-(1S,4S,6S,7R,8S,8aR)-4-chloro-6-(formyloxy)-8-(2-((2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-7-methyl-1,2,3,4,6,7,8,8a-octahydronaphthalen-1-yl 2-methylbutanoate
(S)-(+)-2-甲基丁酸酐
(S)-2-甲基丁酰氯
(1S,3S,7R,8R,8aR)-8-(2-((2R,4R)-4-((tert-butyldimethylsilyl)oxy)-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-6-oxo-1,2,3,4,6,7,8,8a-octahydronaphthalen-1-yl (S)-2-methylbutanoate
(1S,4S,7R,8R,8aR)-8-(2-((2R,4R)-4-((tert-butyldimethylsilyl)oxy)-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-4-chloro-7-methyl-6-oxo-1,2,3,4,6,7,8,8a-octahydronaphthalen-1-yl (S)-2-methylbutanoate
(S)-2-Methyl-butyric acid (1S,3R,7R,8R,8aR)-8-{2-[(2R,4R)-4-(tert-butyl-dimethyl-silanyloxy)-6-oxo-tetrahydro-pyran-2-yl]-ethyl}-3,7-dimethyl-6-oxo-1,2,3,5,6,7,8,8a-octahydro-naphthalen-1-yl ester
(1S-(1α,3α,7β,8β(4Σ*,6R*)8aβ))-((8-(2-(6-(2-(((1,1-dimethylethyl)diphenylsilyl)oxy)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)ethyl)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-1-naphthalenyl)oxy)triethylsilane
(1S-(1α(αS,γR*),5β,6β(4Σ*,6R*)))-6-(2-(6-(2-(((1,1-dimethylethyl)diphenylsilyl)oxy)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)ethyl)-α,5-dimethyl-2-oxo-γ-((triethylsilyl)oxy)-3-cyclohexene-1-butanal
(S)-2-Methyl-butyric acid (1S,3R,7R,8R,8aR)-8-{2-[(2R,4R)-4-(tert-butyl-dimethyl-silanyloxy)-6-oxo-tetrahydro-pyran-2-yl]-ethyl}-3,7-dimethyl-6-trifluoromethanesulfonyloxy-1,2,3,7,8,8a-hexahydro-naphthalen-1-yl ester
(1S-(1α(R*),3α,7β,8β(4S*,6R*),8aβ))-8-(2-(6-(2-(((1,1-dimethylethyl)diphenylsilyl)oxy)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)ethyl)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-1-naphthalenyl 2-methylbutanoate
(1S-(1α,3α,7β,8β(4S*,6R*),8aβ))-8-(2-(6-(2-(((1,1-dimethylethyl)diphenylsilyl)oxy)ethyl)-2,2-dimethyl-1,3-dioxan-4-yl)ethyl)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-1-naphthalenol
<4S-<4α,5α(4S*,4S*),6β(1R*,3S*)>>-5-<2-<6-<2-<<(1,1-dimethylethyl)diphenylsilyl>oxy>ethyl>-2,2-dimethyl-1,3-dioxan-4-yl>ethyl>-6-(1-hydroxy-3-methyl-4-pentenyl)-4-methyl-2-cyclohexen-1-one
(1S,3R,7S,8S,8aR)-8-{2-[(4R,6S)-6-(2-Hydroxy-ethyl)-2,2-dimethyl-[1,3]dioxan-4-yl]-ethyl}-3,7-dimethyl-1,2,3,7,8,8a-hexahydro-naphthalen-1-ol
(1S-(1α(R*),3α,7β,8β(4S*,6R*),8aβ))-8-(2-(2,2-dimethyl-6-(2-oxoethyl)-1,3-dioxan-4-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydro-1-naphthalenyl 2-methylbutanoate
(1S-(1α(R*),3α,7β,8β(4S*,6R*),8aβ))-1,2,3,7,8,8a-hexahydro-8-(2-(6-(2-hydroxyethyl)-2,2-dimethyl-1,3-dioxan-4-yl)ethyl)-3,7-dimethyl-1-naphthalenyl 2-methylbutanoate
6(R)-[2-[1,2,6,7,8,8a(R)-Hexahydro-2(S),6(R)-dimethyl-8(S)-[[2(S)-methylbutyryl]oxy]-1(S)-naphtyl]ethyl]-3,4,5,6-tetrahydro-4(R)-[(tert-butyldimethylsilyl)oxy]-2H-pyran-2-one
