化合物简介
Laropiprant (INN) was a drug used in combination with niacin to reduce blood cholesterol (LDL and VLDL) that is no longer sold, due to increases in side-effects with no cardiovascular benefit. Laropiprant itself has no cholesterol lowering effect, but it reduces facial flushes induced by niacin.
基本信息
中文名称
拉罗皮兰
英文名称
Laropiprant
中文别名
(R)-2-(4-(4-氯苄基)-7-氟-5-(甲基磺酰基)-1,2,3,4-四氢环戊烷并[B]吲哚-3-基)乙酸、(3R)-4-[(4-氯苯基)甲基]-7-氟-1,2,3,4-四氢-5-(甲基磺酰基)-环戊并[b]吲哚-3-乙酸
英文别名
(3R)-[4-(4-chlorobenzyl)-7-fluoro-5-(methane-sulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acid、laropiprant、MK 0524、Laropiprant (INN/USAN)、[(3R)-4-(4-chlorobenzyl)-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acid、(-)-[4-(4-chlorobenzyl)-7-fluoro-5-(methanesulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]-indol-3-yl]acetic acid、UNII-G7N11T8O78、[(3R)-4-(4-chlorophenyl)methyl-7-fluoro-5-(methylsulfonyl)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl]acetic acid、Cyclopent[b]indole-3-acetic acid, 4-[(4-chlorophenyl)methyl]-7-fluoro-1,2,3,4-tetrahydro-5-(methylsulfonyl)-, (3R)-、2-[(3R)-4-[(4-chlorophenyl)methyl]-7-fluoro-5-methylsulfonyl-2,3-dihydro-1H-cyclopenta[b]indol-3-yl]acetic acid
CAS号
571170-77-9
分子式
C21H19ClFNO4S
分子量
435.896
精确质量
435.071
PSA
84.75
LOGP
5.4709
编号系统
UNII
G7N11T8O78
物化性质
外观与性状
白色至米黄色固体
密度
1.486 g/cm3
沸点
710.014ºC at 760 mmHg
熔点
175∶ºC
闪点
383.203ºC
