化合物简介
AZD 7762 is studied as an cancer therapeutic agent due to its selective inhibitory activities towards checkpoint kinases, chk1 and chk2 by reversibly binding their respective ATP-binding sites within tumor cells. Recent research has also indicated AZD 7762 to possess enhancing effects towards other chk1 inhibitor lethality in glioblastoma cells.
基本信息
中文名称
(3R)-1-[4,4-双(3-甲基噻吩-2-基)丁-3-烯基]哌啶-3-甲酸盐酸盐
英文名称
3-(carbamoylamino)-5-(3-fluorophenyl)-N-[(3S)-piperidin-3-yl]thiophene-2-carboxamide
中文别名
3-[(氨基羰基)氨基]-5-(3-氟苯基)-N-(3S)-3-哌啶基-2-噻吩羧胺
英文别名
AZD 7762,AZD7762、AZD7762
CAS号
860352-01-8
分子式
C17H20ClFN4O2S
分子量
398.883
精确质量
398.098
PSA
124.49
LOGP
4.8216
编号系统
MDL号
MFCD12406007
物化性质
密度
1.38
沸点
547.6ºC at 760 mmHg
闪点
285ºC
