化合物简介
Valsartan/sacubitril (brand name Entresto) is a combination drug for use in heart failure developed by Novartis. It consists of the angiotensin receptor blocker valsartan and the neprilysin inhibitor sacubitril, in a 1:1 mixture by molecule count. It may be used instead of an ACE inhibitor or an angiotension receptor blocker in people with heart failure with reduced ejection fraction.
基本信息
中文名称
LCZ696
英文名称
LCZ696
中文别名
英文别名
trisodium [3-((1S,3R)-1-biphenyl-4-ylmethyl-3-ethoxycarbonyl-1-butylcarbamoyl)propionate-(S)-3-methyl-2-(pentanoyl{2”-(tetrazol-5-ylate)biphenyl-4-ylmethyl}amino)butyrate] hemipentahydrate、trisodium 3-((1S,3R)-1-(biphenyl-4-ylmethyl)-3-(ethoxycarbonyl)butylcarbamoyl)propionate (S)-3-methyl-2-(pentanoyl-(2-(tetrazol-1-at-5-yl)biphenyl-4\'-ylmethyl)amino)butyrate hemipentahydrate、Entresto、L-Valine, N-(1-oxopentyl)-N-[[2\'-(2H-tetrazol-5-yl)[1,1\'-biphenyl]-4-yl]methyl]-, compd. with α-ethyl (αR,γS)-γ-[(3-carboxy-1-oxopropyl)amino]-α-methyl[1,1\'-biphenyl]-4-pentanoate, sodium salt, hydrate (2:2:6:5)
CAS号
936623-90-4
分子式
C49H59N6Na3O8
分子量
928.997
精确质量
928.409
PSA
207.53
LOGP
5.9834
编号系统
UNII
WB8FT61183
