化合物简介
Alvocidib (INN; also known as Flavopiridol or HMR-1275) is a flavonoid alkaloid CDK9 kinase inhibitor under clinical development for the treatment of acute myeloid leukemia, by Tolero Pharmaceuticals, Inc. It has been studied also for the treatment of arthritis and atherosclerotic plaque formation The target of Flavopiridol is the positive transcription elongation factor P-TEFb. Treatment of cells with Flavopiridol leads to inhibition of P-TEFb and the loss of mRNA production.
基本信息
中文名称
夫拉平度
英文名称
Flavopiridol
中文别名
磷酸氟达拉滨、FLAVOPIRIDOL、2-(2-氯苯基)-5,7-二羟基-8-[(3S,4R)-3-羟基-1-甲基-4-哌啶基]苯并吡喃、2-(2-氯苯基)-5,7-二羟基-8-[(3S,4R)-3-羟基-1-甲基-4-哌啶基]苯并吡喃-4-酮、HMR-1275
英文别名
Flavopirodol、Alvocidib、Alvocidib,Free Base
CAS号
146426-40-6
分子式
C21H20ClNO5
分子量
401.84
精确质量
401.103
PSA
94.14
LOGP
3.2425
编号系统
MDL号
MFCD20501884
物化性质
外观与性状
黄色粉末
密度
1.448 g/cm3
沸点
603.6ºC at 760 mmHg
闪点
318.8ºC
折射率
1.708
