化合物简介
Conessine is a steroid alkaloid found in a number of plant species from the Apocynaceae family, including Holarrhena floribunda, Holarrhena antidysenterica and Funtumia elastica. It acts as a histamine antagonist, selective for the H3 subtype (with an affinity of pKi = 8.27; Ki = ~5 nM). It was also found to have long CNS clearance times, high blood-brain barrier penetration and high affinity for the adrenergic receptors.
基本信息
中文名称
止泻木碱
英文名称
conessine
中文别名
地麻素
英文别名
CONESSIN、Con-5-enin-3-amine, N,N-dimethyl-, (3β)-、WRIGHTINE、ROQUESSINE、NERVINE、NERIINE、ROGUESSINE、Conessine,N,N-Dimethyl-con-5-enin-3-amine、5-CONENIN-3BETA-DIMETHYLAMINE、1-Deazaadenosine
CAS号
546-06-5
分子式
C24H40N2
分子量
356.588
精确质量
356.319
PSA
6.48
LOGP
4.7475
编号系统
UNII
EZ38J9BBDF
物化性质
密度
1.05g/cm3
沸点
450.4ºC at 760 mmHg
熔点
126-127ºC
闪点
199.6ºC
折射率
1.564
储存条件
Store at RT
