化合物简介
Lomerizine (INN) (also known as KB-2796) is a diphenylpiperazine class L-type and T-type calcium channel blocker. This drug is currently used clinically for the treatment of migraines, while also being used experimentally for the treatment of glaucoma and optic nerve injury.
基本信息
中文名称
洛美利嗪
英文名称
1-[bis(4-fluorophenyl)methyl]-4-[(2,3,4-trimethoxyphenyl)methyl]piperazine
中文别名
1-(二(4-氟苯基)甲基)-4-(2,3,4-三甲氧基苯甲基)哌嗪
英文别名
lomerizine、1-(Bis(p-fluorophenyl)-methyl)-4-(2,3,4-trimethoxybenzyl)piperazine、UNII-DEE37CY4VO、1-[bis(4-fluorphenyl)methyl]-4-(2,3,4-trimethoxybenzyl)piperazin、Terranas、Lomerizine [INN]
CAS号
101477-55-8
分子式
C27H30F2N2O3
分子量
468.536
精确质量
468.222
PSA
34.17
LOGP
4.7736
编号系统
UNII
DEE37CY4VO
物化性质
密度
1.203g/cm3
沸点
527.3ºC at 760mmHg
熔点
213-215ºC
闪点
272.7ºC
蒸汽压
3.31E-11mmHg at 25°C
