化合物简介
Delamanid (USAN, INN) is a drug for the treatment of multi-drug-resistant tuberculosis. It works by blocking the synthesis of mycolic acids in Mycobacterium tuberculosis, the organism which causes tuberculosis, thus destabilising its cell wall. The drug is approved in the EU under the trade name Deltyba (made by Otsuka Pharmaceutical).
基本信息
中文名称
迪拉马尼
英文名称
Delamanid
中文别名
(2R)-2,3-二氢-2-甲基-6-硝基-2-[[4-[4-[4-(三氟甲氧基)苯氧基]-1-哌啶基]苯氧基]甲基]咪唑并[2,1-b]恶唑、(2R)-2,3-二氢-2-甲基-6-硝基-2-[[4-[4-[4-(三氟甲氧基)苯氧基]-1-哌啶基]苯氧基]甲基]咪唑并[2,1-b]噁唑
英文别名
UNII-8OOT6M1PC7、OPC-67683、(2R)-2-methyl-6-nitro-2-[[4-[4-[4-(trifluoromethoxy)phenoxy]piperidin-1-yl]phenoxy]methyl]-3H-imidazo[2,1-b][1,3]oxazole、Imidazo[2,1-b]oxazole, 2,3-dihydro-2-methyl-6-nitro-2-[[4-[4-[4-(trifluoromethoxy)phenoxy]-1-piperidinyl]phenoxy]methyl]-, (2R)-
CAS号
681492-22-8
分子式
C25H25F3N4O6
分子量
534.484
精确质量
534.173
PSA
103.8
LOGP
5.556
物化性质
外观与性状
白色至棕色固体
可溶性
DMSO: ≥ 30 mg/mL
