化合物简介
Urapidil is a sympatholytic antihypertensive drug. It acts as an α1-adrenoceptor antagonist and as an 5-HT1A receptor agonist Although an initial report suggested that urapidil was also an α2-adrenoceptor agonist, this was not substantiated in later studies that demonstrated it was devoid of agonist actions in the dog saphenous vein and the guinea-pig ileum. Unlike some other α1-adrenoceptor antagonists, urapidil does not elicit reflex tachycardia, and this may be related to its weak β1-adrenoceptor antagonist activity, as well as its effect on cardiac vagal drive. Urapidil is currently not approved by the U.S. Food and Drug Administration, but it is available in Europe.
基本信息
中文名称
乌拉地尔
英文名称
6-[3-[4-(2-methoxyphenyl)piperazin-1-yl]propylamino]-1,3-dimethylpyrimidine-2,4-dione
中文别名
6-{3-[4-(2-甲氧基苯基)-1-哌嗪基]-丙基氨基}-1,3-二甲基脲嘧啶、6-[[3-[4-(2-甲氧基苯基)-1-哌嗪基]丙基]氨基]-1,3-二甲基尿嘧啶
英文别名
urapidil(jan)、Urapidilum [INN-Latin]、6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl]propyl]amino]-1,3-dimethyluracil、Ebrantil、urapidil、6-{3-[4-(2-methoxy-phenyl)-piperazin-1-yl]-propylamino}-1,3-dimethyl-1H-pyrimidine-2,4-dione、6-[[3-[4-(2-Methoxyphenyl)-1-piperazinyl)propyl]-amino]-1,3-dimethyluracil、Mediatensyl、Eupressyl、Uraprene、6-({3-[4-(2-methoxyphenyl)piperazin-1-yl]propyl}amino)-1,3-dimethylpyrimidine-2,4-(1H,3H)-dione、1,3-dimethyl-6-[[3-[4-(2-methoxyphenyl)-1-piperazinyl]propyl]amino]-2,4(1H,3H)pyrimidine-dione
CAS号
34661-75-1
分子式
C20H30ClN5O3
分子量
423.937
精确质量
423.204
PSA
71.74
LOGP
1.5947
编号系统
UNII
A78GF17HJS
物化性质
密度
1.26 g/cm3
沸点
549ºC at 760 mmHg
闪点
285.8ºC
折射率
1.622
