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1-脱氧野尻霉素

1-脱氧野尻霉素

CAS号：19130-96-2

英文名：duvoglustat

分子式

C6H13NO4

熔点

195-196°C

密度

1.456 g/cm3

分子量

163.172

沸点

361.1ºC at 760 mmHg

溶解度

信号词

危险品标志

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化合物简介

1-Deoxynojirimycin (DNJ) is an alpha-glucosidase inhibitor, most commonly found in mulberry leaves. Although it can be obtained in small quantities by brewing an herbal tea from mulberry leaves, interest in commercial production has led to research on developing mulberry tea higher in DNJ, and on alternate routes of production, such as via Bacillus species.

基本信息

中文名称

1-脱氧野尻霉素

英文名称

duvoglustat

中文别名

脱氧野尻霉素(1-DNJ)、桑叶提取物、脱氧野尻霉素、1-脱氧氮杂-D-葡萄糖、1-去氧野艽霉素、桑叶脱氧野尻霉素

英文别名

(2R,3R,4R,5S)-2-(Hydroxymethyl)piperidine-3,4,5-triol、Deoxynojirimycin

CAS号

19130-96-2

分子式

C6H13NO4

分子量

163.172

精确质量

163.084

PSA

92.95

LOGP

-2.638

编号系统

UNII

FZ56898FLE

物化性质

外观与性状

白色固体

密度

1.456 g/cm3

沸点

361.1ºC at 760 mmHg

熔点

195-196°C

闪点

197.3ºC

折射率

1.582

稳定性

Stable if stored as directed.

储存条件

This product should be stored at 0ºC. It should be kept in a tightly closed container.

安全信息

安全说明

S26; S37/39; S24/25

WGK Germany

3

危险类别码

R36/37/38

海关编码

2933399090

危险品标志

Xi

合成路线

共找到14条合成路线 >

N-bentyl-2,3,4,6-tetra-O-benzyl-1-deoxynojirimycin

N-bentyl-2,3,4,6-tetra-O-benzyl-1-deoxynojirimycin

1-脱氧野尻霉素

1-脱氧野尻霉素

上游原料

共找到114个上游原料 >

N-benzyl-3,4-di-O-benzyl-1,5-dideoxy-1,5-imino-D-glucitol

N-benzyl-3,4-di-O-benzyl-1,5-dideoxy-1,5-imino-D-glucitol

(2R,3R,4S,5S)-5-(Benzyloxy)-2-(hydroxymethyl)piperidine-3,4-diol

(2R,3R,4S,5S)-5-(Benzyloxy)-2-(hydroxymethyl)piperidine-3,4-diol

1,2-O-异亚丙基-D-呋喃葡萄糖

1,2-O-异亚丙基-D-呋喃葡萄糖

6-azido-6-deoxy-1-O-benzyl-2,3-O-isopropylidene-α-L-sorbofuranose

6-azido-6-deoxy-1-O-benzyl-2,3-O-isopropylidene-α-L-sorbofuranose

野尻霉素

6-azido-6-deoxy-1-O-benzyl-α-L-sorbofuranose

6-azido-6-deoxy-1-O-benzyl-α-L-sorbofuranose

下游产品

共找到11个下游商品 >

N-甲基-1-脱氧尻霉素

N-甲基-1-脱氧尻霉素

N-苄氧羰基-4,6-O-苯基亚甲基脱氧野尻霉素

N-苄氧羰基-4,6-O-苯基亚甲基脱氧野尻霉素

2-乙酰氨基-1,2,5-三脱氧-1,5-亚氨基-d-葡萄糖醇

2-乙酰氨基-1,2,5-三脱氧-1,5-亚氨基-d-葡萄糖醇

tert-butyl (2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidine-1-carboxylate

tert-butyl (2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidine-1-carboxylate

N-叔丁氧羰基-1,5-亚氨基-D-山梨糖醇

N-叔丁氧羰基-1,5-亚氨基-D-山梨糖醇

米格鲁他

上游原料

N-benzyl-3,4-di-O-benzyl-1,5-dideoxy-1,5-imino-D-glucitol (2R,3R,4S,5S)-5-(Benzyloxy)-2-(hydroxymethyl)piperidine-3,4-diol 1,2-O-异亚丙基-D-呋喃葡萄糖 6-azido-6-deoxy-1-O-benzyl-2,3-O-isopropylidene-α-L-sorbofuranose 野尻霉素 6-azido-6-deoxy-1-O-benzyl-α-L-sorbofuranose N-benzyl-1-deoxynojirimycin (2R,3R,4R,5S)-3,4,5-三(苄氧基)-2-[(苄氧基)甲基]哌啶 (E)-methyl 3-((4S,5S)-5-(((tert-butyldimethylsilyl)oxy)methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)acrylate N-benzyloxycarbonyl-2,4-di-O-benzyl-1,5-dideoxy-1,5-imino-D-glucitol [2-azido-2-(6-benzyloxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)ethoxy]-tert-butyl dimethylsilane (2S,3S,4R,5R)-5-azido-2,3-(isopropylenedioxy)-4,6-bis(methoxymethoxy)hexan-1-ol (2R,3R,4S,5S)-2-azido-6-<(tert-butyldimethylsilyl)oxy>-4,5-(isopropylidenedioxy)hexane-1,3-diol 3,6-di-O-benzyl-5-azido-5-deoxy-α/β-D-glucofuranose (2R,3R,4S,5S)-4,5-(isopropylenedioxy)-3-(methoxymethoxy)-2-<(methoxymethoxy)methyl>piperidine 5-叠氮基-5-脱氧-alpha-D-呋喃葡萄糖 (E)-ethyl (4S,5S)-4,5-dihydroxy-6-(4-methoxybenzyloxy)-hex-2-enoate (2R,3R,4R,5S)-(3,4-dibenzyloxy-N-tert-butoxycarbonyl-5-hydroxy-2-piperidinyl)methanol Vinbarbital (+)-(3aR,5RS,6R,6aS)-3a,5,6,6a-tetrahydro-5,6-dihydroxyfuro<2,3-d>isoxazole-3-methanol D-xylo-hexos-5-ulose N-Benzhydryl-1-deoxynojirimycin (E)-(4S,5S)-6-<(tert-Butyldimethylsilyl)oxy>-4,5-O-(1-methylethylidene)-2-hexen-1-ol 6-Amino-6-desoxy-L-sorbofuranose-hydrochlorid 5-amino-5-deoxy-D-glucose-1-sulfonic acid 1-(6-benzyloxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)-2-(tert-butyldimethylsiloxy)ethanol (2R,3R,4R,5S)-3-benzyloxy-2-benzyloxymethyl-4,5-isopropylidenedioxypiperidine 二丙酮-D-葡萄糖 (2R,4aR,7S,8R,8aR)-tert-butyl 8-hydroxy-7-(methoxymethyl)-2-phenyltetrahydro-4H-[1,3]dioxino[5,4-b]pyridine-5(4aH)-carboxylate ((2R,3R,4R,5S)-3,4,5-tris(benzyloxy)piperidin-2-yl)methanol 2-azido-2-(6-benzyloxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxole-5-yl)ethanol methanesulfonic acid (6-benzyloxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxol-5-yl)-2-(tert-butyldimethylsiloxy)ethyl ester 1,2-O-异亚丙基-5-氧代-alpha-D-葡萄糖 D-fructofuranose 1-O-benzyl-2,3-O-isopropylidene-α-L-sorbofuranose (2S,3S,4R,5R)-5-azido-1-<(tert-butyldimethylsilyl)oxy>-2,3-(isopropylenedioxy)-4,6-bis(methoxymethoxy)hexane 2,3,4-tri-O-benzyl-L-idose dimethyl acetal 双丙酮-L-山梨糖 (2S,3R,4R,5S)-6-<(tert-butyldimethylsilyl)oxy>-2,3-epoxy-4,5-(isopropylidenedioxy)hexan-1-ol 3-O-苄基-1,2:5,6-O-双异丙叉-α-D-呋喃葡萄糖 (E)-3-((4S,5S)-5-((4-ethoxybenzyloxy)methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)prop-2-en-1-ol (2S-trans)-3-(3-p-methoxybenzyloxymethyl-1S,2S-O-isopropylidenepropyl)oxiranemethanol ethyl (E)-3-((4S,5S)-5-((4-methoxybenzyloxy)methyl)-2,2-dimethyl-1,3-dioxolan-4-yl)acrylate (2S,3S,4R,5R)-5-azido-2,3-(isopropylenedioxy)-4,6-bis(methoxymethoxy)-1-<(methylsulfonyl)oxy>hexane 6-deoxy-6-amino-L-sorbofuranose N-bentyl-2,3,4,6-tetra-O-benzyl-1-deoxynojirimycin 1-O-benzyl-2,3:4,6-di-O-isopropylidene-α-L-sorbofuranose

下游产品

N-甲基-1-脱氧尻霉素 N-苄氧羰基-4,6-O-苯基亚甲基脱氧野尻霉素 2-乙酰氨基-1,2,5-三脱氧-1,5-亚氨基-d-葡萄糖醇 tert-butyl (2R,3R,4R,5S)-3,4,5-trihydroxy-2-(hydroxymethyl)piperidine-1-carboxylate N-叔丁氧羰基-1,5-亚氨基-D-山梨糖醇米格鲁他去氧野艽霉素盐酸盐 4-O-alpha-D-吡喃葡萄糖基脱二氧亚胺基葡糖醇 5-氨基-5-脱氧葡萄糖酸delta-内酰胺 (2R,3R,4R,5S)-2-(hydroxymethyl)-1-(4,4,4-trifluorobutyl)piperidine-3,4,5-triol 米各尼醇